An in situ rapid prototyping magnetic hydrogel for urinary system repair and its preparation method

Abstract

The invention discloses an in-situ rapid prototyping magnetic hydrogel for urinary system repair and a preparation method thereof. The magnetic hydrogel is a double network hydrogel, including monomer acrylamide, cross-linking agent and photoinitiator of the first heavy network, carboxymethyl chitosan and magnetic nanoparticle γ-Fe of the second heavy network 2 o 3 The preparation method of the in-situ rapid prototyping magnetic hydrogel comprises: injecting the hydrogel precursor in situ at the injury of the human urinary system, such as vesico-vaginal fistula, which is rapidly formed under 405 nanometer blue light for 5 seconds, Forms a hydrogel that adapts to the shape of the inner wall of the vesicovaginal fistula. The magnetic hydrogel provided by the invention has the properties of in-situ rapid prototyping, high swelling rate, traceability, etc., and can promote cell adhesion, thus speeding up the repair of damaged parts. The in-situ rapid prototyping magnetic hydrogel has a simple preparation process and simple surgical operation, and is convenient for large-scale production from the perspective of industrialization.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to an in-situ rapid prototyping magnetic hydrogel for urinary system repair and a preparation method thereof. Background technique [0002] A bladder fistula is the partial or complete excretion of urine through an abnormal channel in the bladder or through another organ in the body. Among them, vesicovaginal fistula is the most common. It is an abnormal fistula between the bladder and the vagina. The clinical manifestation is continuous leakage of urine, which is easy to cause infection and seriously affects the quality of life. The current repair operation often needs to take autologous tissue as filler, such as omentum, muscle flap and so on. There are problems such as complicated operation, large trauma, and potential complications. [0003] As a three-dimensional polymer network with high water content, hydrogel is often used as an implant in the body because i...

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Problems solved by technology

[0005] The main purpose of the present invention is to provide an in-situ rapid prototyping magnetic hydrogel for urinary system repair and its preparation method, so as to overcome the existing defects of difficult operation and poor mechanical properties in the prior art

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