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Solid-phase polypeptide synthesis device

A solid-phase peptide synthesis and box technology, which is applied in feeding devices, chemical/physical/physical-chemical stationary reactors, chemical/physical/physical-chemical processes, etc., can solve the problems of low efficiency and labor consumption, and achieve The effect of convenient cleaning, stable operation of the device, and avoiding the phenomenon of sticking to the barrel wall

Inactive Publication Date: 2021-04-09
黑龙江思莱博科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of labor-intensive and low efficiency in the prior art, and propose a solid-phase peptide synthesis device

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] refer to Figure 1-5, a solid-phase polypeptide synthesis device, comprising a heat transfer box 1, a synthesis barrel 2 is fixedly connected to the inner wall of the heat transfer box 1, a servo motor 3 is fixed to the center of the outer top surface of the synthesis barrel 2 through screws, and the servo motor 3 The output end passes through the top surface of the synthesis barrel 2 and is fixedly connected with the stirring paddle 4, the inner bottom surface of the synthesis barrel 2 is fixedly connected with the heating plate 5, and the inner wall of the lower end of the synthesis barrel 2 is also fixedly connected with the heat transfer plate 6, and the center position of the bottom surface of the synthesis barrel 2 is also fixed. A discharge pipe 7 is connected through it, a solenoid valve 8 is fixedly installed on the inner wall of the discharge pipe 7, and a material injection mechanism 9 is also installed on one side of the top surface of the synthesis barrel 2,...

Embodiment 2

[0034] like figure 2 and 5 As shown, this embodiment is basically the same as Embodiment 1. Preferably, a hollow ring 27 is fixedly connected to the inner wall of the upper end of the synthetic bucket 2, and a water mist nozzle 28 is installed on the bottom surface of the hollow ring 27. There is also a gap between the hollow ring 27 and the water inlet pipe 12. A water guide pipe 29 is connected through, and a control valve three 30 is installed on the water guide pipe 29 .

[0035] A plurality of water mist nozzles 28 are evenly distributed on the inner bottom surface of the hollow ring 27 .

[0036] In this embodiment, a hollow ring 27 is fixedly connected to the inner wall of the upper end of the synthetic barrel 2. After the solid-phase polypeptide is discharged, the control valve 2 13 is closed and the control valve 3 30 is opened, and the hot water is pumped under the action of the water pump 14. into the hollow ring 27 and sprayed out from the water mist nozzle 28, ...

Embodiment 3

[0038] like figure 1 and 2 As shown, this embodiment is basically the same as Embodiment 1. Preferably, a support plate 31 is fixedly connected between the lower end of the water tank 10 and the storage box 16 and the side wall of the heat transfer box 1, and the first water pump 14 and the second water pump 19 All are fixed on the top surface of the support plate 31 by screws.

[0039] In this embodiment, the first water pump 14 and the second water pump 19 are fixed on the top surface of the support plate 31 by screws, so that the first water pump 14 and the second water pump 19 work more stably.

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Abstract

The invention discloses a solid-phase polypeptide synthesis device which comprises a heat transfer box body, wherein a synthesis barrel is fixedly connected to the inner wall of the heat transfer box body; a servo motor is fixedly connected to the center of the outer top surface of the synthesis barrel through screws, wherein the output end of the servo motor penetrates through the top surface of the synthesis barrel and is fixedly connected with a stirring paddle, and a heating piece is fixedly connected to the inner bottom surface of the synthesis barrel; a heat transfer plate is further fixedly connected to the inner wall of the lower end of the synthesis barrel, a discharging pipe is further connected to the center of the bottom face of the synthesis barrel in a penetrating mode, an electromagnetic valve is fixedly installed on the inner wall of the discharging pipe, a material injection mechanism is further installed on one side of the top face of the synthesis barrel and comprises a discharging barrel and an air pump, and the discharging barrel is connected to the top face of the synthesis barrel. The device is reasonable in design and stable in operation, so that the phenomenon that reactants are attached to the wall of the barrel is well avoided by adding materials to the stickers in a slow injection mode, and the device is convenient to clean, so that a certain guarantee is provided for high-quality and high-efficiency preparation of solid-phase polypeptides.

Description

technical field [0001] The invention relates to the technical field of solid-phase polypeptide production equipment, in particular to a solid-phase polypeptide synthesis device. Background technique [0002] Polypeptide is a compound formed by linking α-amino acids with peptide bonds. It is an intermediate product of protein hydrolysis. The compound formed by dehydration and condensation of two amino acid molecules is called dipeptide. Similarly, there are tripeptides, tetrapeptides, and pentapeptides. etc. Usually, the compound formed by the dehydration condensation of 10 to 100 amino acid molecules is called a polypeptide, which requires the use of a synthesis device. [0003] After searching, the patent with application number 201921912922.4 discloses a solid-phase peptide synthesis device, including a peptide synthesis cylinder with an opening on the upper side and a cylinder cover with a sealing cover on the upper end of the polypeptide synthesis cylinder, and the lower...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/18B01J4/00
CPCB01J19/0046B01J19/0013B01J19/0006B01J19/0053B01J19/18B01J4/001B01J2204/002B01J2219/00058B01J2219/00162B01J2219/00092B01J2219/00085
Inventor 刘天野常利君金福厚梁超王东升吴强杨雷
Owner 黑龙江思莱博科技股份有限公司