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Application of deferoxamine mesylate in preparation of medicine for treating otitis media

A technology for deferoxamine mesylate and otitis media, which is applied in the field of medicine, and can solve problems such as skin rash, diarrhea, otitis media protracted healing, and chronic otitis media.

Active Publication Date: 2021-05-18
QINGDAO UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For children with moderate to severe earache and high fever, the current common clinical treatment method is mainly antibiotics and anti-inflammation. This method is likely to cause side effects such as rash and diarrhea. Some patients will also develop otitis media that persists for a long time, and it turns into chronic otitis media. Case
There are no reports on the use of deferoxamine mesylate in the treatment of otitis media

Method used

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  • Application of deferoxamine mesylate in preparation of medicine for treating otitis media
  • Application of deferoxamine mesylate in preparation of medicine for treating otitis media
  • Application of deferoxamine mesylate in preparation of medicine for treating otitis media

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 1. OM mouse model construction and RPM treatment

[0019] Take 6–8 week-old C57BL / 6J mice (from Jackson Laboratory), measure their ABR threshold, select 25 mice with normal ABR threshold, including 10 female mice and 15 male mice, and divide them into Randomly divided into five groups.

[0020] The mice in each group were anesthetized with 4% chloral hydrate, and the following drugs were injected into the middle ear cavity of the mice in each group through the tympanic membrane using a Hamilton syringe: normal saline (NS), PGPS (100 μg), PGPS (100 μg)+DFO (100 μg ), PGPS (100 μg) + DFO (200 μg), PGPS (100 μg) + DFO (400 μg), the drugs were all dissolved in normal saline, and the injection volume was 10 μL.

[0021] 2. Auditory Brainstem Response (ABR)

[0022] The ABR threshold of C57BL / 6J mice was evaluated before and on the third day after PGPS injection:

[0023] Anesthetize the mouse with 4% chloral hydrate and keep its body temperature at 37°C; insert the active...

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Abstract

The invention discloses application of deferoxamine mesylate in preparation of a medicine for treating otitis media, and belongs to the technical field of medicines. The deferoxamine mesylate can relieve the inflammatory response of otitis media and relieve hearing loss caused by otitis media, and the treatment effect is remarkable.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of deferoxamine mesylate in the preparation of medicines for treating otitis media. Background technique [0002] Otitis media (Otitis medium, OM) is a common disease in otolaryngology; for children, otitis media is one of the causes of hearing loss, and seriously affects children's language development. For children with moderate to severe ear pain and high fever, the current common clinical treatment method is mainly antibiotics and anti-inflammation. This method is likely to cause side effects such as rash and diarrhea. Some patients may also develop otitis media that persists for a long time and turns into chronic otitis media. Case. Therefore, it is necessary to find safer and more effective therapeutic drugs. [0003] Desferrioxamine mesylate (DFO) is a ferroptosis inhibitor that binds free iron to a stable complex to reduce the toxicity o...

Claims

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Application Information

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IPC IPC(8): A61K31/16A61P27/16A61P29/00
CPCA61K31/16A61P27/16A61P29/00Y02A50/30
Inventor 李博郑庆印颜斌郑体花谢道莉张肖林
Owner QINGDAO UNIV