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Ultrathin Gd doped T1-T2 dual-mode MRI contrast agent and preparation method thereof

A technology of T1-T2 and contrast agent, which is applied in the direction of pharmaceutical formulations, preparations for in vivo tests, emulsion delivery, etc. It can solve the problems of unsatisfactory contrast performance and achieve the effect of low Gd content and high performance

Inactive Publication Date: 2021-05-25
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Traditional Gd complex contrast agents and various newly developed nano-gadolinium particle contrast agents, due to structural limitations, contrast performance is not ideal (commercial contrast agent r 1 only about 3-5 mM -1 the s -1 ), and due to the certain toxicity of gadolinium, it is hoped that the dosage of Gd can be greatly reduced and the performance of contrast agent can be improved

Method used

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  • Ultrathin Gd doped T1-T2 dual-mode MRI contrast agent and preparation method thereof
  • Ultrathin Gd doped T1-T2 dual-mode MRI contrast agent and preparation method thereof
  • Ultrathin Gd doped T1-T2 dual-mode MRI contrast agent and preparation method thereof

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Embodiment 1

[0021] a.[ Y 1.8 Gd 0.2 (OH) 5 (H 2 O) n ] C 6 h 5 COO rare earth hydroxide layered material powder refers to the open literature "Ln 2 (OH) 5 NO 3 ·xH 2 0 (Ln=Y,Gd-Lu) : A Novel Family of Anion ExchangeIntercalation Hosts";

[0022] b. Take 0.1g of the above powder and 0.1g of sodium polyacrylate (PAA) in 200ml of distilled water and mix well;

[0023] c. Under the condition of ice-water bath at 0°C, the cell disruptor was sonicated at 100w power for 10 minutes, and after standing at room temperature for 24 hours, the supernatant was taken, which was the negatively charged [Y 1.8 Gd 0.2 (OH) 5 (H 2 O) n ] C 6 h 5 COO ultrathin nanosheet sol, which is the ultrathin Gd-doped T 1 -T 2 Dual-mode MRI contrast agents.

[0024] The ultrathin Gd-doped T 1 -T 2 The TEM and AFM characterization of the dual-mode MRI contrast agent proves that the thickness of the contrast agent is about 1.5 nm. Its TEM spectrum is shown in figure 1 ; AFM spectrum see figure 2...

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Abstract

The invention discloses an ultrathin Gd-doped T1-T2 dual-mode MRI contrast agent and a preparation method thereof. According to the ultrathin single-layer Gd-doped T1-T2 dual-mode MRI contrast agent prepared through the method, sodium polyacrylate (PAA) serves as a dispersing agent and a stripping agent, Gd-doped ultrathin single-layer yttrium hydroxide nanosheet sol is obtained through ultrasonic treatment in an ice-water bath, and the Gd-doped ultrathin single-layer yttrium hydroxide nanosheet sol has ultrahigh r1 and r2 relaxation rates. The ultrathin Gd-doped T1-T2 dual-mode MRI contrast agent nanosheet prepared by the invention has a two-dimensional interstitial Gd-doped structure single-layer structure, extremely high Gd atom utilization rate, simple preparation method, high stability and good hydrophilicity.

Description

technical field [0001] The invention relates to chemical synthesis material technology and its application, in particular to an ultra-thin Gd-doped T 1 -T 2 Dual-mode MRI contrast agent and preparation method thereof. Background technique [0002] For the clinical diagnosis and treatment of malignant diseases such as tumors, MRI detection is increasingly playing an increasingly important role. Currently, 40-50% of clinical MRI examinations already use contrast agents to increase sensitivity to distinguish background tissue from diagnostically valuable regions. For gadolinium contrast, usually T 1 Contrast agents can enhance signal strength, produce brighter images with positive contrast enhancement, have high image sensitivity and spatial registration accuracy, but lack the beneficial high contrast-to-noise ratio. Iron-based contrast agent-based T 2 contrast agent at T 2 Negative contrast enhancement (darker image) is provided in weighting. Although it has high sensiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/18B82Y25/00B82Y30/00B82Y40/00
CPCA61K49/126B82Y25/00B82Y30/00B82Y40/00A61K49/1803
Inventor 李强李鑫戴梦婷王文慧缪佳燕衡月容于翠艳刘苏苏潘鑫
Owner EAST CHINA NORMAL UNIV