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Breast cancer prognosis prediction molecular marker and application thereof

A breast cancer and molecular technology, applied in the direction of medical preparations containing active ingredients, drug combinations, analytical materials, etc., can solve the problem of no effective prognosis prediction molecular markers, etc., and achieve simple and economical detection methods, easy to understand, and intuitive models Effect

Active Publication Date: 2021-06-04
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, except for ER and HER2, which can partially predict the prognosis of breast cancer, there are no other effective prognostic predictors.

Method used

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  • Breast cancer prognosis prediction molecular marker and application thereof
  • Breast cancer prognosis prediction molecular marker and application thereof
  • Breast cancer prognosis prediction molecular marker and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1 Research Design

[0033] Prospective cohort study.

[0034] 2 research objects

[0035] Source: Inpatients in the Department of Breast Cancer, Sun Yat-sen University Cancer Hospital.

[0036] Inclusion criteria: female patients with primary invasive breast cancer diagnosed by pathology between January 2008 and December 2015, with a tumor diameter greater than 1 cm.

[0037] Exclusion criteria: history of malignant tumors, psychiatric history, cognitive impairment (such as senile dementia), severe illness (such as coma or shock), language barriers, etc. who cannot complete the questionnaire; in addition, those who have undergone biopsy or puncture or have undergone quick frozen Patients were also excluded.

[0038] According to these criteria, 1063 effective breast cancer new cases were finally collected in this study, and 9 cases were lost to follow-up.

[0039] This study was approved by the Ethics Committee of the School of Public Health, Sun Yat-sen University,...

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Abstract

The invention relates to the field of breast cancer prognosis diagnosis, in particular to a breast cancer prognosis prediction molecular marker and application thereof. The invention provides an application of a molecule for detecting histone in preparation of a kit or a detection reagent for predicting the prognosis condition of breast cancer. The histone comprises one or more of H3K4me2, H3K9me2, H3K27me3, H4K20me3 and H4K5ac. By detecting expression levels of various histone proteins in more than 1000 breast cancer tissue specimens, tracking for more than 10 years to obtain prognosis conditions (death and relapse) of the breast cancer tissue specimens, analyzing the relationship between the expression levels of the histone proteins and prognosis, screening out five histone markers closely related to prognosis, providing a prognosis and survival probability prediction line diagram of the breast cancer patients, the clinical prediction of the disease-progression-free survival and total survival probability of the breast cancer patient is improved.

Description

technical field [0001] The invention relates to the field of prognosis diagnosis of breast cancer, in particular to a molecular marker for prognosis prediction of breast cancer and its application. Background technique [0002] Breast cancer is the malignant tumor with the most incidence among women at home and abroad, and its overall prognosis is good. The 5-year survival rate can reach 80% (in my country), but the middle and late stage patients are as low as 20%. The existing treatment methods are generally conventional chemotherapy or radiotherapy on the basis of surgery, supplemented by endocrine or targeted therapy, the latter two are only effective in estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER2). When it is positive, ER and HER2 become the targets of breast cancer treatment. At the same time, ER and HER2 are also clinically widely used molecular markers for predicting the prognosis of breast cancer. [0003] After endocrine or targeted t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68A61K45/00A61P35/00
CPCG01N33/57415G01N33/57484G01N33/68A61K45/00A61P35/00G01N2333/47
Inventor 任泽舫陈倩欣
Owner SUN YAT SEN UNIV