Traditional Chinese medicine composition for improving asthenopia as well as preparation method and application of traditional Chinese medicine composition

A composition and eye fatigue technology, applied in the field of traditional Chinese medicine, can solve the problems of inconspicuous drug effect and complicated prescription, and achieve the effect of short melting time, good stability and uniform particles

Active Publication Date: 2021-06-15
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional Chinese medicine composition disclosed in the prior ar

Method used

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  • Traditional Chinese medicine composition for improving asthenopia as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for improving asthenopia as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for improving asthenopia as well as preparation method and application of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] A preparation method for improving the crude drug extract of asthenopia, comprises the following steps:

[0059] S1: In terms of parts by mass, take 8g of Chrysanthemum chrysanthemum and 4g of safflower, heat and reflux extract with 20 times the mass of 40% ethanol for 3 times, each extraction time is 2h, combine the alcohol extracts, concentrate under reduced pressure until no alcohol smell, Centrifuge in a centrifuge (25°C, 7000r / min, 30min), take the supernatant, which is the alcohol-free extract; the alcohol-free extract is prepared as a sample solution of 0.2g crude drug / mL, pH=4.90 , the weight of the crude drug is based on the weighed raw material; since ethanol is easy to elute the substances adsorbed by the macroporous resin, the alcohol extract needs to be concentrated under reduced pressure until it has no alcohol smell before it can be loaded on the macroporous adsorption resin column. At the same time of concentration, some substances will precipitate, so i...

Embodiment 2

[0062] A preparation method for improving the crude drug extract of asthenopia, comprises the following steps:

[0063] S1: In terms of parts by mass, take 16g of Chrysanthemum chrysanthemum and 12g of safflower, heat and reflux extraction with 10 times the mass of 20% ethanol for 4 times, each extraction time is 0.5h, combine the alcohol extracts, and concentrate under reduced pressure until there is no alcohol smell , centrifuged, and the supernatant was taken, which was the alcohol-free extract;

[0064] S2: Take H1020 macroporous adsorption resin, wet-pack the column according to the diameter-to-height ratio of 1:3, then take 0.5BV of alcohol-free extract and load it on the macroporous adsorption resin column at a flow rate of 1BV / h, and then use 0.72BV concentration of 0.05mol / L NaCl solution removes impurities from the macroporous adsorption resin column at a flow rate of 1BV / h, then elutes with 1.8BV of 40% ethanol at a flow rate of 1BV / h, discards the first 0.5BV efflu...

Embodiment 3

[0066] A preparation method for improving the crude drug extract of asthenopia, comprises the following steps:

[0067] S1: In terms of parts by mass, take 24g of Chrysanthemum chrysanthemum and 8g of safflower, heat and reflux extract with 25 times the mass of 80% ethanol once, each extraction time is 1.5h, combine the alcohol extracts, and concentrate under reduced pressure until there is no alcohol smell , centrifuged, and the supernatant was taken, which was the alcohol-free extract;

[0068] S2: Take HPD600 macroporous adsorption resin, and wet-pack the column according to the diameter-to-height ratio of 1:5, then take 1.3BV of alcohol-free extract and load it on the macroporous adsorption resin column at a flow rate of 3BV / h, and then use 1.26BV with a concentration of 0.2mol / L NaCl solution removes impurities from the macroporous adsorption resin column at a flow rate of 3BV / h, then elutes with 2.7BV of 80% ethanol at a flow rate of 3BV / h, discards the first 0.57BV effl...

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Abstract

The invention discloses a traditional Chinese medicine composition for improving asthenopia. The traditional Chinese medicine composition for improving the asthenopia is prepared from chrysanthemum morifolium ramat and flos carthami. The invention also discloses a preparation method of bulk drug extract. The preparation method of the bulk drug extract comprises the steps: taking bulk drugs, carrying out heating reflux extraction with ethanol to obtain an alcohol extract, removing ethanol from the alcohol extract, loading the alcohol extract to a macroporous adsorption resin column, removing impurities with a NaCl solution, eluting with ethanol, and drying an eluent to obtain the bulk drug extract. The invention also discloses a preparation method of the traditional Chinese medicine composition, that is, effervescent granules. The preparation method of the traditional Chinese medicine composition comprises the following steps: uniformly mixing 5-25 parts of the bulk drug extract, 5-25 parts of a diluent and 50-70 parts of effervescent disintegrant, dividing the mixture into two parts, uniformly mixing one part with citric acid to prepare acid granules, uniformly mixing the other part with sodium bicarbonate wrapped by PEG-6000 to prepare alkali granules, and uniformly mixing and granulating the acid granules with the alkali granules to prepare the effervescent granules. The invention also discloses application of the traditional Chinese medicine composition as a medicine for improving the asthenopia, and the curative effect of improving the asthenopia is obvious.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for improving visual fatigue, a preparation method and an application thereof. Background technique [0002] Visual fatigue is a syndrome of eye or systemic organic factors and mental and psychological factors intertwined, belonging to the category of physical and mental medicine; Syndrome is often called eye fatigue syndrome clinically. In recent years, with the acceleration of the pace of society, the increase of pressure in work, life and spirit, and the long-term work and life in front of the computer, the incidence of visual fatigue has been increasing year by year, and patients with visual fatigue are also more and more prone to younger. Visual fatigue will not only seriously interfere with the vision and quality of life of patients, but also further cause age-related macular degeneration, cataracts, blindness and othe...

Claims

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Application Information

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IPC IPC(8): A61K36/287A61K9/16A61K47/36A61K47/26A61K47/10A61K47/02A61K47/12A61P27/02A61P39/06
CPCA61K36/287A61K36/286A61P27/02A61P39/06A61K9/1623A61K9/1652A61K9/0007A61K9/1611A61K9/1641A61K2236/333A61K2236/55A61K2300/00
Inventor 吴素香石森林任敏霞郑碧莹
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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