Universal automated metabolite collection device for rats and mice

Abstract

The invention provides a universal automatic metabolite collection device for rats and mice, which includes a metabolic unit and a collection unit, and the metabolic unit includes a breeding cage and a feces and urine separator. The collection unit includes: a preservation box, a collection tray, a control assembly, a detection assembly and a purge assembly. Both the collection tray and the control assembly are arranged inside the preservation box, and a plurality of urine collection test tubes are arranged on the collection tray, and the collection tray can be driven to switch the urine collection test tubes through the control assembly. The detection component includes a drinking water detector and a urine collection detector. The drinking water information can be detected through the drinking water detector, and the urine collection information can be detected by the urine collection detector. Adaptive purging of the excrement-urine separator is performed based on the difference between the urine volume information and the urine collection volume information. The invention creates the universal automatic metabolite collection device for rats and mice, which can improve the degree of automation in the collection of metabolites in experimental mice and improve the accuracy of sample collection.

Description

technical field [0001] The invention belongs to the field of experimental equipment, and in particular relates to a universal automatic metabolite collection device for rats and mice. Background technique [0002] In the prior art, due to the advantages of good biological stability, easy replication of disease models and low experimental cost, experimental mice are widely used in the research process of physiology, pharmacology and metabolic diseases. When conducting research, researchers need to raise experimental mice in metabolic cages, monitor the food intake, water intake and excretion of experimental mice, and collect and analyze their metabolites, so as to analyze the metabolism of drugs or nutrients in animals. Situation research. [0003] However, the existing metabolic cages for experimental mice generally have the problem of low degree of automation. Due to the low degree of automation of metabolic cages, when it is necessary to collect metabolite samples at mul...

AI Technical Summary

Problems solved by technology

This will not only consume a lot of time and cost, but also affect the living conditions of experimental mice due to frequent manual intervention, thereby reducing the accuracy of metabolic experiment results

[0004] In addition, the existing metabolic cages still have the problem of low sample collection accuracy in the urine collection of experimental mice

Because the urine of the experimental mice will inevitably remain in the metabolic cage, the volume of urine collected in the experiment often has errors from the actual results

Especially when using small experimental mice for experiments, because the urine volume of mice is small, the residual urine will amplify the influence of collection errors, resulting in inaccurate experimental results

Secondly, during the continuous collection of multiple samples, the residual urine in the metabolic cage will also pollute subsequent samples

After being contaminated, the composition of the sample will change, which will lead to errors in the analysis results, which will further affect the accuracy of the metabolism experiment

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