A kind of medical natural polymer microsphere containing radionuclide and its preparation method and application
A technology of natural polymers and radionuclides, applied in the field of medical natural polymer microspheres containing radionuclides and its preparation, to achieve the effects of stable structure, simple preparation method, and good clinical transformation feasibility
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0046] Embodiment 1. Preparation of medical natural polymer microspheres
[0047] S1, weigh 5g of chitosan and dissolve it in 100mL of deionized water, mix well under ultrasonic and heating conditions, adjust the pH to 3 with 0.1M HCl, then add 10wt% NaIO to the reaction device 4 , at 40°C for 3 hours. After the reaction, add 10 mL of 0.1M ethylene glycol solution to terminate the oxidation reaction for 1 hour. Put the reaction solution into a dialysis bag with a molecular weight cut-off of 8000-14000 and place it in deionized water for dialysis. 3 days, and finally freeze-drying obtains aldehydated chitosan;
[0048] S2, weigh 1g of aldehylated chitosan, 0.5g of GelMA and 0.05g of lithium phenyl (2,4,6-trimethylbenzoyl) phosphate and mix it with phosphate buffer solution at 50°C, Filter with a 0.45 μm filter head to obtain the dispersed phase; then measure 40 mL of n-octane solution and 2 mL of Span-80 as the continuous phase, and use such as figure 1 The microfluidic devic...
Embodiment 2
[0053] S1, weigh 3g of sodium alginate and dissolve it in a three-necked brown flask filled with 60mL of deionized water, mix well under ultrasonic and heating conditions, adjust the pH to 3 with 0.1M HCl, and then add 20wt% NaIO to the reaction device 4 , at 40°C for 4 hours. After the reaction, add 6 mL of 0.1M ethylene glycol solution to terminate the oxidation reaction for 1.5 hours. Put the reaction solution into a dialysis bag with a molecular weight cut-off of 8000-14000 and place it in deionized water. Dialysis for 3 days, and finally freeze-drying to obtain alginate sodium alginate;
[0054] S2, weigh 1.5g of alginate sodium alginate, 0.8g of GelMA and mix with phosphate buffer solution evenly at 40°C, filter while hot with a 0.45μm filter head to obtain the dispersed phase; then measure 50mL of liquid paraffin and 3mL of Class-60 is used as the continuous phase, such as figure 1 The microfluidic device shown (the flow rate ratio of the dispersed phase and the contin...
Embodiment 3
[0059] S1, weigh 6g of starch and dissolve it in a three-necked brown flask with 100mL of deionized water, adjust the pH to 2 with 0.1M HCl, then add 10wt% NaIO to the reaction device 4 , oxidation reaction at 40°C for 4 hours, after the reaction is over, add 10 mL of 0.1M ethylene glycol solution to terminate the oxidation reaction for 2 hours, put the reaction solution into a dialysis bag with a molecular weight cut-off of 8000-14000, place it in deionized water for dialysis 3 days, and finally freeze-dried to obtain the formylated starch;
[0060] S2. Weigh 2g of aldylated starch and 1g of GelMA and mix them evenly with phosphate buffer solution at 50°C, filter while hot with a 0.45μm filter head to obtain the dispersed phase; then measure 60mL of rapeseed oil and 4mL of Span-80 As the continuous phase, using such as figure 1 The microfluidic device shown (the flow rate ratio of the dispersed phase and the continuous phase is 1:20) prepares microsphere droplets to obtain m...
PUM
| Property | Measurement | Unit |
|---|---|---|
| penetration depth | aaaaa | aaaaa |
| diameter | aaaaa | aaaaa |
| diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More