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Methods of treating follicular lymphoma
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A lymphoma and follicular technology, applied in the field of treatment of follicular lymphoma, can solve the problem of complex gene map of follicular lymphoma
Pending Publication Date: 2021-07-23
JANSSEN BIOTECH INC
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[0004] The genetic profile of follicular lymphoma is complex
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[0053] The following examples are provided to further describe some of the embodiments disclosed herein. These examples are intended to illustrate, not limit, the disclosed embodiments of the invention.
[0054] Identification of genetic signatures enriched for response to ibrutinib in relapsed / refractory follicular lymphoma (FL)
[0055] The DAWN study (NCT01779791) evaluated the efficacy and safety of ibrutinib monotherapy in patients with relapsed / refractory (R / R) follicular lymphoma (FL). The overall response rate (ORR) for ibrutinib was 20.9% (95% confidence interval [CI], 13.7-29.7), and the primary endpoint was not met. However, responders experienced long-duration responses (median 19.4 months). A genetic study was performed on samples from the DAWN study to determine whether somatic mutations could be used to identify FL patients who would respond or not respond to ibrutinib.
[0056] Study Design and Patients
[0057] The detailed method of the DAWNassay is ...
Embodiment approach 1
[0103] Embodiment 1. The use of ibrutinib in the manufacture of a medicament for the treatment of a subject who does not have one or more mutations as defined in Table 2 in one or more genes selected from Follicular lymphoma (FL): AHNAK, ARID1A, ATP6AP1, BCL9L, CLTC, CNOT1, EP400, KDM2B, MYBBP1A, NACA, NBPF1, NBPF10, NCOA4, NEDD4L, PRDM16, SOCS1, and TBL1XR1.
Embodiment approach 2
[0104]Embodiment 2. Use of ilu for the treatment of follicular lymphoma (FL) in a subject not having one or more mutations as defined in Table 2 in one or more genes selected from tinib: AHNAK, ARID1A, ATP6AP1, BCL9L, CLTC, CNOT1, EP400, KDM2B, MYBBP1A, NACA, NBPF1, NBPF10, NCOA4, NEDD4L, PRDM16, SOCS1, and TBL1XR1.
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[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application 62 / 773,678, filed November 30, 2018, the disclosure of which is hereby incorporated by reference in its entirety. technical field [0003] Provided herein are methods of treating follicular lymphoma (FL) and genetic mutations that can be used to predict a subject's non-response to treatment of follicular lymphoma with ibrutinib. Background technique [0004] The genetic profile of follicular lymphoma is complex. In addition to the marker t(14;18) translocation leading to BCL2 overexpression, molecular genetic studies have also identified recurrent somatic mutations in a number of genes. Such mutations can reduce a subject's response to treatment. Contents of the invention [0005] Provided herein is a method of treating follicular lymphoma (FL) in a subject, the method comprising administering to the subject a therapeutically effective amount of ibruti...
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