Application of seabuckthorn polysaccharide in preparing preparations for preventing and/or treating porcine pseudorabies virus infection
A technique for porcine pseudorabies and seabuckthorn polysaccharides, which is applied in the field of application of seabuckthorn polysaccharides in the preparation of preparations for preventing and/or treating porcine pseudorabies virus infection, can solve the problems that the virus inhibitory effect has not been reported, and achieve small preparation pollution and reduce cell Lesions, high safety effect
Active Publication Date: 2022-04-15
YANGZHOU UNIV
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Problems solved by technology
However, the inhibitory effect of Hippophae rhamnoides polysaccharide (HRP) on viruses has not been reported
Method used
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Embodiment 1
[0043] A preparation for preventing and / or treating porcine pseudorabies virus infection. Seabuckthorn polysaccharide (Ciyuan Biotechnology Co., Ltd.) is dissolved in PBS buffer solution, and the concentration of seabuckthorn polysaccharide is 250 μg / mL.
Embodiment 2
[0045] A preparation for preventing and / or treating porcine pseudorabies virus infection. The seabuckthorn polysaccharide is dissolved in PBS buffer solution, and the concentration of the seabuckthorn polysaccharide is 500 μg / mL.
Embodiment 3
[0047] A preparation for preventing and / or treating porcine pseudorabies virus infection, comprising dissolving seabuckthorn polysaccharide in PBS buffer, and the concentration of seabuckthorn polysaccharide is 750 μg / mL.
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Abstract
The invention discloses the application of seabuckthorn polysaccharide in preparing preparations for preventing and / or treating porcine pseudorabies virus infection. The invention proves through in vitro cell experiments that the seabuckthorn polysaccharide can effectively inhibit porcine pseudorabies virus infection, and can significantly reduce cell pathological changes caused by porcine pseudorabies virus. By adding seabuckthorn polysaccharides at different stages of virus infection, it was found that seabuckthorn polysaccharides mainly inhibit the adsorption, entry and replication of viruses to cells. The invention provides a safe, effective and less toxic and side effect preparation for clinical prevention and / or treatment of porcine pseudorabies virus infection.
Description
technical field [0001] The invention belongs to the field of antiviral applications, and in particular relates to the application of seabuckthorn polysaccharides in the preparation of preparations for preventing and / or treating porcine pseudorabies virus infection. Background technique [0002] Pseudorabies (PR), also known as Aujeszky's disease (AD), is an acute and severe infectious disease caused by pseudorabies virus (PRV), mainly causing a variety of livestock and wild animals Symptoms such as fever, itching, and encephalomyelitis. PRV is a double-stranded DNA virus belonging to the subfamily A and Herpesviridae. Although PRV can infect a variety of mammals, such as dogs, cats, cattle, sheep, and rabbits, pigs are the only natural host. Porcine pseudorabies is one of the important diseases that endanger the pig industry. Pigs of all ages and sexes are susceptible to porcine pseudorabies virus. The infection of newborn piglets can lead to 100% mortality, which has caus...
Claims
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IPC IPC(8): A61K31/715A61K36/185A61P31/22
CPCA61K31/715A61K36/185A61P31/22
Inventor 郇长超张伟刘金彪尼博高崧
Owner YANGZHOU UNIV
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