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Medical adhesive capable of promoting wound healing and preparation method therefor

A wound healing and adhesive technology, which is applied in the field of medical adhesives for promoting wound healing and its preparation, can solve the problem of low adhesive strength and the like, achieves low equipment requirements, is suitable for large-scale production, and is well biodegradable. sexual effect

Active Publication Date: 2021-08-06
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this adhesive has the disadvantage that the adhesive strength is not high

Method used

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  • Medical adhesive capable of promoting wound healing and preparation method therefor
  • Medical adhesive capable of promoting wound healing and preparation method therefor
  • Medical adhesive capable of promoting wound healing and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Weigh 3g of polylactic acid and 0.5g of Mrcp-20k protein isolated from barnacle gum, add 100mL of deionized water and disperse under the condition of heating and stirring at 60°C;

[0028] (2) After cooling down to room temperature, 1 g of lectin and 1 g of snail mucus (collected by oneself) were added, stirred to obtain a medical adhesive, and stored at 4°C until use.

Embodiment 2

[0033] Embodiment 2: Adhesive strength test and comparison

[0034] Adhesive strength test method: The treated pigskin is thawed in a 37°C water bath, cut into 1×4cm 2 For the sample, the surface moisture was fully absorbed with absorbent paper and kept at 37°C. The medical adhesive made in embodiment 1 and comparative example 1,2 is coated on pigskin surface (1 * 3cm 2 ), glue the two pieces of pigskin together, lightly press them with your fingers for 30 seconds, keep them warm in a water bath at 37°C, and test the uniaxial tensile stress of the sample on a universal mechanical testing machine with a 50N load cell at a crosshead rate of 5mm / min- Strain test. Each stretch to break as the final maximum adhesive force, calculate the corresponding adhesive strength, the results are as follows figure 1 shown. It can be seen from the figure that the addition of Mrcp-20k protein helps to increase the adhesive strength of the adhesive, and the combination of Mrcp-20k protein an...

Embodiment 3

[0035] Embodiment 3: in vitro degradation experiment

[0036] The adhesives prepared in Example 1 and Comparative Examples 1 and 2 were freeze-dried, and the freeze-dried adhesives were soaked in Tris buffer, placed in a constant temperature shaking box (37°C, 80r / min), measured and calculated The weight loss rate was used to characterize the in vitro degradation performance. Shake well at 37°C and 100rpm / min, then take out some samples at 3, 6, 9, 12, 15, 18 and 21 days respectively, vacuum dry at 60°C to constant weight, weigh and calculate the concentration of the taken out samples W i . W 0is the concentration of the original lyophilized binder. Then the weight loss rate (%) is calculated according to the formula:

[0037] Weight loss rate (%)=(W0-Wi) / (W0)×100.

[0038] The results of the in vitro degradation experiments of the adhesive are as follows: figure 2 Shown: the in vitro degradation test result of adhesive of the present invention is as figure 2 As show...

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Abstract

The invention relates to a medical adhesive capable of promoting wound healing and a preparation method therefor. The medical adhesive comprises polylactic acid, a Mrcp-20k protein, agglutinin and a snail mucilage. The medical adhesive disclosed by the invention has good biocompatibility and biodegradability, is high in adhesive strength and can be tightly attached to a wound, thus, the wound healing is better promoted, and secondary injury caused by drug removal can be effectively avoided. The preparation method for the medical adhesive is simple, the equipment requirements are not high, the raw materials are readily available, the cost is low, and thus, the medical adhesive is suitable for being produced on a large scale.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a medical adhesive for promoting wound healing and a preparation method thereof. Background technique [0002] Biomaterials are a class of high-tech materials used to diagnose, repair or enhance the functions of human tissues and organs, that is, natural or artificial materials used to replace and repair living tissues, and their functions cannot be replaced by drugs. Biomaterials can perform, enhance or replace a certain function lost due to disease, injury, etc., but cannot restore the defective part. Since the late 1990s, the world's biomaterial science and technology have developed rapidly. Even in today's global economic downturn, biomaterials still maintain a rapid growth rate of 13% per year, which fully reflects its strong vitality and broad development prospects. Modern medicine is developing in the direction of regeneration and reconstruction of damaged ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/04A61L24/00
CPCA61L24/108A61L24/046A61L24/0005A61L24/0042A61L24/0015A61L2300/412A61L2300/404A61L2300/41C08L89/00C08L67/04
Inventor 路英慧王艳娟宫春梅
Owner JILIN UNIV
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