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Anti-tumor drug

A technology of anti-tumor drugs and total saponins, which is applied in the field of drugs, can solve the problems of unreported and different drug applications, and achieve the effects of improving the effect, inhibiting tumor growth, and inducing tumor apoptosis

Pending Publication Date: 2021-08-10
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Solidago securrens total saponin and flavone (SDSF) is a natural compound, which is obviously different from the commonly used cytotoxic anti-tumor drugs, and the application of SDSF as a chemotherapeutic synergist has not been reported yet

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0026] an antineoplastic drug

[0027] The present embodiment provides a kind of antitumor drug, and it is made up of the normal saline solution of the total flavonoid saponins of solidago solidagoides total saponins that concentration is 0.2g / mL and the apigenin normal saline solution that concentration is 70mmol / mL, respectively with volume ratio 1: The ratio of 1000 is added in the diluent, wherein the volume ratio of the saline solution of the total flavonoids and total saponins of Solidago solidago to the saline solution of apigenin is 1:1. In this example, the diluent is RMPI-1640 medium suitable for cell experiments. In other embodiments, the diluent may also be physiological saline or other medically acceptable solvents.

[0028] In the present embodiment, the steps of the configuration method of the physiological saline solution of the total flavonoids and total saponins of Solidago solidago are as follows:

[0029] Step 1, take the whole plant of Solidago, crush it...

Embodiment 2

[0038] an antineoplastic drug

[0039] The present embodiment provides a kind of antitumor drug, and it is made up of the normal saline solution of the total flavonoid saponins of solidago solidagoides total saponins that concentration is 0.2g / mL and the apigenin normal saline solution that concentration is 35mmol / mL, respectively with volume ratio 1: The ratio of 1000 is added in the diluent, wherein the volume ratio of the saline solution of the total flavonoids and total saponins of Solidago solidago to the saline solution of apigenin is 1:1. In this example, the diluent is RMPI-1640 medium suitable for cell experiments. In other embodiments, the diluent may also be physiological saline or other medically acceptable solvents.

[0040] In this embodiment, the preparation method of the physiological saline solution of the total flavonoids and total saponins of Solidago solidago is the same as that in Embodiment 1, and will not be repeated here.

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Abstract

The invention provides an anti-tumor drug, and belongs to the field of drugs. The anti-tumor drug comprises solidago decurrens total flavone total saponins and apigenin, and particularly comprises a solidago decurrens total flavone total saponin solution with the concentration of 0.2 mg / mL and an apigenin solution with the concentration of 70 [mu] mol / mL. According to the invention, the solidago decurrens total flavonoid total saponins (SDSF) and the traditional anti-tumor chemotherapeutic drug apigenin are creatively combined for use so that the anti-tumor drug can obviously improve the cancer treatment effect of the apigenin, and can further obviously inhibit tumor growth and induce tumor apoptosis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an antitumor medicine, in particular to an antitumor medicine containing total flavonoids, total saponins of Solidago solidago and apigenin. Background technique [0002] Common tumor chemotherapy drugs have good therapeutic effects but have relatively large side effects. Traditional Chinese medicine assisting Western medicine in the treatment of tumors has positive significance in enhancing the efficacy of chemotherapy drugs, improving the body's immunity, prolonging survival, reducing recurrence and metastasis rates, and reducing side effects. [0003] Solidago genus of Asteraceae contains more than 120 sub-categories, mainly growing in North America. There are 4 varieties in my country, namely Solidago, Solidago trichocarpa, Solidago canadensis and Solidago obtuse. The chemical components of different varieties also vary. difference. Solidago mainly contains flavonoids, saponins, ben...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P35/00A61K31/352
CPCA61K36/28A61K31/352A61P35/00A61K2300/00
Inventor 席晨卫丹
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV