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Pulullan-modified ginsenoside Rg3 nanostructure lipid carrier and preparation method thereof

A nanostructured lipid and pullulan technology, applied in nanotechnology, nanotechnology, nanopharmaceuticals, etc., can solve the problems of low solubility, limited clinical application, poor oral absorption effect, etc., to promote uptake and improve anti-tumor effect of action

Pending Publication Date: 2021-08-17
宿迁市第一人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ginsenoside Rg 3 Low solubility in water and poor oral absorption, which limit its clinical application

Method used

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  • Pulullan-modified ginsenoside Rg3 nanostructure lipid carrier and preparation method thereof
  • Pulullan-modified ginsenoside Rg3 nanostructure lipid carrier and preparation method thereof
  • Pulullan-modified ginsenoside Rg3 nanostructure lipid carrier and preparation method thereof

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Embodiment 1

[0026] This example discloses a pullulan-modified ginsenoside Rg 3 A method for preparing a nanostructured lipid carrier, comprising the steps of:

[0027] S1. 60mg glyceryl monostearate, 16mg ginsenoside Rg 3 , 20mg of phospholipids and 19mg of linoleic acid were added to 10mL of absolute ethanol solvent, heated and dissolved to obtain an organic phase;

[0028] S2. Dissolve 22mgPUL and 100mgTPGS in 10mL of water;

[0029] S6. Slowly inject the organic phase obtained in S1 into the mixed solution of PUL and TPGS obtained in S2 under stirring at 1200r / min; stir at a constant temperature of 60-70°C to volatilize the organic solvent, and obtain a translucent emulsion after 2 hours, which is translucent to translucent The emulsion is ultrasonically mixed to obtain PUL-Rg 3 -NLC dispersion.

[0030] This embodiment sets control group, and the preparation method of control group is:

[0031] S1. Glyceryl monostearate, ginsenoside Rg 3 , phospholipids, and linoleic acid are ad...

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Abstract

The invention discloses a pullulan-modified ginsenoside Rg3 nanostructure lipid carrier and a preparation method thereof. In the carrier, a nanostructure lipid carrier (NLC) wraps ginsenoside Rg3, the outer side of the nanostructure lipid carrier is modified by pullulan (PUL), and the adhesiveness of the nanostructure lipid carrier is improved. According to the invention, the pullulan (PUL)-modified ginsenoside Rg3 nanostructure lipid carrier is constructed, can be retained in gastric tissues for a long time, promotes oral absorption of ginsenoside Rg3, and mainly promotes uptake of ginsenoside Rg3 by human gastric adenocarcinoma cells BGC-823 through an endocytosis pathway mediated by caveolae. The pullulan-modified ginsenoside Rg3 nanostructure lipid carrier has the characteristic of stomach adhesion, can be retained in stomach tissues for a long time, promotes drug uptake of gastric cancer cells, and improves anti-tumor effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a pullulan-modified ginsenoside Rg 3 Nanostructured lipid carrier and its preparation method. Background technique [0002] Ginseng is the dried root of Panax ginseng in the Araliaceae family. It is a traditional and precious Chinese medicinal material in my country. It has the effects of nourishing vitality, nourishing qi and lungs, calming the nerves and improving intelligence. It has a long history of medicinal use and is known as the "King of Herbs". , wherein ginsenoside is the main active ingredient in ginseng. In recent years, studies have found that ginsenoside Rg in its chemical composition 3 It has significant antitumor effect. Clinically, ginsenoside Rg 3 The combination of monomer preparation Shenyi Capsule and chemotherapy is widely used in various tumors. Ginsenoside Rg 3 It has low solubility in water and poor oral absorption, which limits its clinical application. C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K31/704A61P35/00B82Y5/00B82Y40/00
CPCA61K47/61A61K31/704A61P35/00B82Y5/00B82Y40/00
Inventor 杨青金鑫蔡宁袁菱李爽
Owner 宿迁市第一人民医院