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Lanosterol eye drops and preparation method thereof

A technology of lanosterol and eye drops, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of limited application, no obvious benefit in prevention, etc. Wetting effect, increasing lacrimal gland secretion, preventing or adjuvant treatment of cataract

Active Publication Date: 2021-09-21
东莞博盛生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing lanosterol eye drops mainly treat cataracts, and generally need to be used according to the doctor's advice, the application is relatively limited, and there is no obvious benefit for relieving eye fatigue and preventing eye diseases such as iris and ciliary body

Method used

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  • Lanosterol eye drops and preparation method thereof
  • Lanosterol eye drops and preparation method thereof
  • Lanosterol eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of lanosterol eye drop, comprises the raw material of following percentage by weight:

[0035]

[0036]

[0037] The balance is water for injection;

[0038] The traditional Chinese medicine extract is the extract of honeysuckle, wild chrysanthemum, cassia, forsythia, witch hazel, angelica and herb.

[0039] Wherein, the lanosterol compound is lanosterol

[0040] Wherein, the thickener is composed of chitosan and hydroxypropyl methylcellulose in a weight ratio of 1:1.5.

[0041] Wherein, the Chinese medicine extract is made of the following raw materials in parts by weight:

[0042]

[0043] Wherein, the preparation method of the traditional Chinese medicine extract is as follows: weigh honeysuckle, wild chrysanthemum, cassia, forsythia, witch hazel, angelica and atractylodes in parts by weight and grind them, then add them to water, distill at 70°C for 4 hours, and then filter , and take the filtrate to obtain the traditional Chinese medicine extract...

Embodiment 2

[0046] A kind of lanosterol eye drop, comprises the raw material of following percentage by weight:

[0047]

[0048] The balance is water for injection;

[0049] The traditional Chinese medicine extract is the extract of honeysuckle, wild chrysanthemum, cassia, forsythia, witch hazel, angelica and herb.

[0050] Wherein, the lanosterol compound is dihydrolanosterol.

[0051] Wherein, the thickener is composed of chitosan and hydroxypropyl methylcellulose in a ratio of 1:1 by weight.

[0052] Wherein, the Chinese medicine extract is made of the following raw materials in parts by weight:

[0053]

[0054] Wherein, the preparation method of the traditional Chinese medicine extract is as follows: weigh honeysuckle, wild chrysanthemum, cassia, forsythia, witch hazel, angelica and atractylodes in parts by weight and grind them, then add them to water, distill at 60°C for 3 hours, and then filter , and take the filtrate to obtain the traditional Chinese medicine extract. ...

Embodiment 3

[0057] A kind of lanosterol eye drop, comprises the raw material of following percentage by weight:

[0058]

[0059] The balance is water for injection;

[0060] The traditional Chinese medicine extract is the extract of honeysuckle, wild chrysanthemum, cassia, forsythia, witch hazel, angelica and herb.

[0061] Wherein, the lanosterol compound is 1,4-desmethyllanosterol.

[0062]Wherein, the thickener is composed of chitosan and hydroxypropyl methylcellulose in a ratio of 1:2 by weight.

[0063] Wherein, the Chinese medicine extract is made of the following raw materials in parts by weight:

[0064]

[0065]

[0066] Wherein, the preparation method of the traditional Chinese medicine extract is as follows: weigh honeysuckle, wild chrysanthemum, cassia, forsythia, witch hazel, angelica and atractylodes in parts by weight and grind them, then add them to water, distill at 80°C for 5h, and then filter , and take the filtrate to obtain the traditional Chinese medicin...

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Abstract

The invention relates to the technical field of eye drops, in particular to lanosterol eye drops and a preparation method thereof. The eye drops comprise lanosterol compounds, vitamin A, vitamin E, a traditional Chinese medicine extract and a thickening agent. According to the eye drops, the lanosterol compound is used as a main material, the effect of preventing or assisting in treating cataract is achieved, low-dosage vitamin A and vitamin E are added, vitamin A can increase lacrimal gland secretion and has a good improvement effect on xerophthalmia, vitamin E has an anti-oxidation effect, eyes are protected from being attacked by free radicals, and the thickening agent is added to improve the emulsification dispersity, so that the wetting effect of the eye drops is ensured. In addition, the traditional Chinese medicine extracting solution extracted from various traditional Chinese medicines is added, and the eye drops have the effects of removing nebula and improving eyesight and have good prevention and treatment effects on xerophthalmia, blurred vision, cataract and the like.

Description

technical field [0001] The invention relates to the technical field of eye drops, in particular to a lanosterol eye drop and a preparation method thereof. Background technique [0002] All kinds of reasons, such as aging, heredity, local nutritional disorders, immune and metabolic abnormalities, trauma, poisoning, radiation, etc., can cause lens metabolic disorders, resulting in lens protein denaturation and turbidity, which is called cataract. Obstruction cannot be projected on the retina, resulting in blurred vision. It is more common in people over 40 years old, and the incidence rate increases with age. [0003] At present, there is no clinical drug that can effectively treat cataracts, and affected individuals can only improve vision through surgery to replace intraocular lenses. Recent literature has demonstrated that steroid molecules can reduce the severity of cataracts in the eyes of animals (Quinlan 2015). Among them, lanosterol (Lanosterol) has been proven to r...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/08A61K47/36A61K47/38A61P27/02A61P27/12A61K31/07A61K31/355A61K31/575
CPCA61K36/355A61K36/287A61K36/482A61K36/634A61K36/185A61K36/232A61K36/284A61K31/575A61K31/07A61K31/355A61K47/36A61K47/38A61K9/08A61K9/0048A61P27/12A61P27/02A61K2300/00
Inventor 刘昕欧海航罗维方赖强江榆贵彭小珍
Owner 东莞博盛生物科技有限公司
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