A preparation method of antibacterial agarose-based coating with low blood adhesion

Abstract

The invention belongs to the field of new polymer functional materials, and discloses a preparation method of an agarose-based coating with low blood adhesion and antibacterial properties. Using a simple two-step method, the precursor is first prepared by reacting an excess of polyfunctional amino resin with polydimethylsiloxane, which is then reacted with the hydroxyl groups of agarose to prepare the coating. Both agarose and polydimethylsiloxane have good biocompatibility and are non-toxic, and the agarose is renewable and degradable. The combination of agarose and polydimethylsiloxane is achieved through strong cross-linking to inhibit chemical remodeling, while polydimethylsiloxane reduces the surface energy, making the coating have excellent anti-liquid adhesion properties, which is expected to be used in biological And in the fields of antifouling, antibacterial and anti-blood adhesion of medical devices.

Description

technical field [0001] The invention belongs to the field of novel polymer functional materials, and more particularly relates to a preparation method of a low blood adhesion antibacterial agarose-based coating. Background technique [0002] In recent years, low-adhesion coatings that do not stick to liquids have broad application prospects in the fields of antifouling and self-cleaning, liquid transportation, and drag reduction. The low liquid adhesion properties of such materials are affected by the morphology of the material surface and the chemical composition of the surface. In addition, the demand for anti-adhesion materials in the medical field is even higher, in which the adhesion of biological tissues on medical devices and blood adhesion problems prevent many materials from being applied in this field. In particular, for medical devices, such materials should also have certain biocompatibility. However, at present, the preparation conditions of the existing low-a...

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Problems solved by technology

Among them, rough surface materials with micro-nano structure and monomolecular layer anti-adhesion materials have problems such as non-wear resistance, and SLIPs also have the problem of loss of lubricating liquid components.

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