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Bear gall oral liquid as well as preparation method and application thereof

A technology of bear bile oral liquid and bear bile, which is applied in the field of medicine to achieve good taste, improve bioavailability, and avoid first-pass effect

Pending Publication Date: 2021-10-15
江西国妙堂生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no bear bile medicine liquid preparation that fundamentally solves the problem of its extreme bitterness and fishy smell, and is suitable for children, the elderly, and patients with dysphagia.

Method used

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  • Bear gall oral liquid as well as preparation method and application thereof
  • Bear gall oral liquid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Bear bile containing bear bile powder 15g, boiled for 30 minutes to sterilize, filter, add 90g of beta-cyclodextrin, add 20% ethanol of the medicinal solution, continue heating and stirring to dissolve, stir and clathrate at 85°C for 60min, evaporate Remove or recycle ethanol to form bear bile clathrate; boil 510g of sucrose with drinking water to make simple syrup for later use; decoct 85g of honey and filter it through a 100-mesh stainless steel sieve to remove impurities, and process it into honey refining for later use; menthol 4g, Dissolve 3 g of ethylparaben in ethanol for later use; mix bear bile inclusion medicine, simple syrup and refined honey, add bear bile inclusion medicine, ethylparaben ethanol solution, stir and mix, and wait until the temperature drops to Below 60°C, add menthol ethanol solution and orange essence, stir 5g and mix well. If necessary, adjust the relative density of the solution to reach 1.20-1.25kg / m 3 That is, bear bile oral liquid. Pa...

Embodiment 2

[0080] With embodiment 1, difference is that the bear bile raw material is the bear bile powder aqueous solution containing 15g bear bile powder.

Embodiment 3

[0082] Dissolve 30g of bear bile powder in water to make an appropriate amount of bear bile aqueous solution, boil and filter, add 180g of beta-cyclodextrin, add 30% ethanol of the medicinal solution, continue heating to dissolve and dissolve, and stir at 60-90°C for inclusion After 60 minutes, wave away or recycle ethanol to form bear bile clathrate; boil 428g of sucrose with drinking water to make simple syrup for later use; decoct 70g of honey and filter it through a 100-mesh stainless steel sieve to remove impurities, and process it into refined honey for later use; mint Brain 4g and ethylparaben 3g were dissolved in ethanol respectively for later use; the bear bile inclusion liquid, simple syrup and refined honey were mixed, added bear bile inclusion liquid, ethylparaben ethanol solution, stirred and mixed, and waited When the temperature drops below 60°C, add menthol ethanol solution and orange essence 5g, stir and mix evenly. If necessary, adjust the relative density of...

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PUM

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Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to bear gall oral liquid and a preparation method and application thereof. The bear gall oral liquid is prepared from, by weight, 15-30 parts of bear gall raw materials, 90-180 parts of beta-cyclodextrin, 350-540 parts of saccharose, 60-110 parts of honey, 3-5 parts of menthol, 2-3 parts of ethylparaben and 3-6 parts of essence, wherein the bear gall raw materials are bear gall powder or bear bile. According to the bear gall powder, the bear gall is taken as a main component, and the bear gall powder subjected to molecular inclusion fundamentally overcomes the problems of extremely bitter taste and fishy smell of the bear gall and the bear gall in a preparation; the bear gall oral liquid prepared by matching the bear gall with other auxiliary materials is good in taste, free of toxic and side effects, capable of maintaining the original components and styles of the bear gall and the natural physiological activity and the specific treatment effect of the bear gall, wide in applicability, especially suitable for children, old people and patients with dysphagia to take, and convenient to transport, store, carry and take.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a bear bile oral liquid and a preparation method and application thereof. Background technique [0002] Bear bile is a dry product of bile obtained from black bears of the bear family through gallbladder surgery. It has the functions of clearing away heat, calming the liver and improving eyesight. Bear bile is one of the four famous and precious animal medicines. It has a history of more than 2,000 years of use as a medicine. However, due to the extremely bitter taste and fishy smell of bear bile, patients have poor compliance with taking it, and even have adverse reactions such as vomiting when taking it. For example, bear bile is particularly effective in treating jaundice hepatitis, convulsions and convulsions caused by high fever. These two diseases often occur in infants and children, but because of their bitter and fishy effects, they are rarely used clinicall...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K35/413A61K47/69A61K47/26A61K47/46A61P1/16A61P25/08A23L33/00A23L29/30
CPCA61K9/0095A61K35/413A61K47/6951A61K47/26A61K47/46A61P1/16A61P25/08A23L33/00A23L29/35A23V2002/00A23V2200/30A23V2250/5112A23V2250/628A23V2250/21A23V2250/082
Inventor 谭养成
Owner 江西国妙堂生物医药科技有限公司