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Diagnostic products and applications of pulmonary hypertension based on biomarkers

A biomarker and product technology, applied in the field of biomedicine, can solve problems such as the difficulty of early PH diagnosis, achieve the effects of reducing disability and mortality, improving detection ability and efficiency, and delaying the progress of PH

Active Publication Date: 2021-11-30
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing cardiac catheterization and imaging examinations are difficult to diagnose early PH

Method used

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  • Diagnostic products and applications of pulmonary hypertension based on biomarkers
  • Diagnostic products and applications of pulmonary hypertension based on biomarkers
  • Diagnostic products and applications of pulmonary hypertension based on biomarkers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 Detection of Biomarkers Related to Pulmonary Hypertension

[0065] 1. Sample collection

[0066] Collect blood samples from 7 patients with chronic thromboembolic pulmonary hypertension (CTEPH) and 5 healthy control groups, and record the basic information of the patients and healthy control groups in detail, including age, gender, BMI, etc., among which the disease group There was no statistical difference with the healthy group in age, gender, BMI, etc.

[0067] Disease group inclusion criteria: CTEPH was diagnosed by right heart catheterization, pulmonary ventilation perfusion scan or CT pulmonary angiography (CTPA). The diagnosis of CTEPH needs to meet the following three conditions at the same time: ① Effective anticoagulant therapy has been performed for at least 3 months to exclude subacute PTE; ② V / Q imaging scan shows at least one pulmonary segment perfusion defect, or multi-slice spiral CT pulmonary artery Imaging (computed tomography pul-monaryang...

Embodiment 2

[0107] Example 2 Verification of differential genes and detection of diagnostic efficacy

[0108] 1. Data and preprocessing

[0109] Download the gene expression data of pulmonary arterial hypertension and its control dataset GSE33463 from the GEO database, and use the annotation file to annotate it. The average value of multiple probes corresponding to the same gene is taken as its expression level, and then the gene expression matrix file is obtained.

[0110] 2. Differential expression analysis

[0111] Expression analysis of differential genes was performed using the "limma" package in R software.

[0112] The analysis results showed that the expressions of PVALB and KCNA5 were significantly up-regulated in patients with pulmonary arterial hypertension, and the expression of SPNS3 was significantly down-regulated in patients with pulmonary arterial hypertension. Figure 1-3 As shown, among them, *: P<0.05; **: P<0.01; ***: P<0.001.

[0113] 3. Analysis of diagnostic eff...

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Abstract

The invention discloses a diagnostic product of pulmonary hypertension based on a biomarker and an application thereof, wherein the biomarker is selected from KCNA5, SPNS3 and / or PVALB. Compared with normal controls, KCNA5, SPNS3, and PVALB showed significant differences in pulmonary arterial hypertension. The diagnostic efficacy results showed that KCNA5, SPNS3, and / or PVALB had higher accuracy, sensitivity, and specificity in the diagnosis of pulmonary arterial hypertension.

Description

technical field [0001] The invention relates to the field of biomedicine, and relates to a diagnostic product of pulmonary arterial hypertension based on a biomarker and an application thereof. Background technique [0002] Pulmonary hypertension (PH) is a group of chronic progressive diseases characterized by progressive increase in pulmonary vascular resistance and progressive failure of right heart function. It is defined as mean pulmonary artery pressure (mPAP) greater than 25 mmHg measured by right heart catheterization at sea level at rest or greater than 30 mmHg during exercise, while pulmonary artery wedge pressure (PAWP) is less than 15 mmHg. The etiology and classification of PH are relatively complex, and can be divided into arterial pulmonary hypertension, pulmonary hypertension caused by left heart disease, pulmonary hypertension caused by hypoxia and / or lung disease, chronic thromboembolic pulmonary hypertension, and multiple mechanisms according to its etiolog...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883G01N33/6893C12Q2600/158G01N2800/12G01N2800/321G01N2333/47
Inventor 刘敏孙学彪孟夏培陶新曹
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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