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Polypeptide FLCQWP with antioxidant function and application thereof

An anti-oxidant and antioxidant technology, applied in the biological field, can solve problems such as human health and safety effects

Pending Publication Date: 2021-10-22
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antioxidants commonly used in the market such as tert-butyl p-hydroxyanisole (BHA), di-tert-butyl p-cresol (BHT), and tert-butyl hydroquinone (TBHQ) can effectively inhibit oxidation, but they are harmful to human body. Health also has a certain potential safety impact, and currently countries have also formulated use limits

Method used

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  • Polypeptide FLCQWP with antioxidant function and application thereof
  • Polypeptide FLCQWP with antioxidant function and application thereof
  • Polypeptide FLCQWP with antioxidant function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Total antioxidant activity of hexapeptide FLCQWP at a concentration of 0.5 mg / mL:

[0025] Detection method: The hexapeptide FLCQWP obtained by chemical synthesis is subjected to activity detection (the detection method is the same as above). At this time, the concentration of the hexapeptide FLCQWP was 0.5 mg / mL.

[0026] Results: The total antioxidant activity of the hexapeptide FLCQWP at 0.5 mg / mL was 0.52mmoL / L TE, and the ability to inhibit hydroxyl free radicals was 10.5U / mL.

[0027] Through the activity data of embodiment 1 (corresponding figure 1 "untreated"), indicating that the hexapeptide FLCQWP has good antioxidant activity.

[0028] After placing 0.5mg / mL hexapeptide FLCQWP solution at 80°C and 100°C for 1h, the measured antioxidant activity was as follows: figure 1 .

[0029] The hexapeptide structure has antioxidant activity has not been reported, is a new functional peptide with antioxidant activity, and has good thermal stability.

Embodiment 2

[0033] Embodiment 2, the application of antioxidant peptide

[0034] 1. After fully mixing 45% of the antioxidant peptide, 30% of lactose and 25% of microcrystalline cellulose, the tablet is compressed by a tablet machine to manufacture a tablet with antioxidant effect.

[0035] 2. Nutritional drink with anti-oxidation function: Mix the ingredients of the drink according to the following proportions: 10% fruit juice, 0.2% citric acid, 8% white sugar, 1% antioxidant peptide, and 80.8% water to make a drink with anti-oxidative function fruit juice.

[0036] The above-mentioned % are all mass %.

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PUM

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Abstract

The invention belongs to the technical field of biology, and particularly relates to a hexapeptide with antioxidant activity and an application thereof. The invention discloses a polypeptide FLCQWP with an antioxidant function. The amino acid sequence of the polypeptide FLCQWP is Phe-Leu-Cys-Gln-Trp-Pro. The invention also discloses an application of the polypeptide FLCQWP as an antioxidant at the same time.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to a hexapeptide with antioxidant activity and its application. Background technique [0002] The physiological metabolism of the human body will produce some oxygen-containing free radicals. If these oxygen-containing free radicals cannot be removed in time, they will react with biological macromolecules such as DNA and protein in the human body to generate oxides or peroxides, which will affect people's normal functioning. Physiological metabolism, and then produce cancer, coronary heart disease, diabetes and other diseases. In addition, in the process of food storage and transportation, food, especially oily food, is prone to oxidation reaction, resulting in changes in the flavor and nutritional content of food, and even producing some harmful substances, reducing food quality and nutritional value, and causing certain harm to the human body. [0003] Antioxidants can scavenge free ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K38/08A61P17/18
CPCC07K7/06A61P17/18A61K38/00
Inventor 张玉王伟王君虹李雪孙素玲白丽萍
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES