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An antimicrobial mixture

An anti-microbial and anti-microbial agent technology, applied in detergent compositions, chemicals for biological control, biocides, etc., can solve the problems that mold growth cannot be prevented, there is no predictability, and it is not suitable for hay preservation

Active Publication Date: 2021-10-22
SYMRISE GMBH & CO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4-Hydroxyacetophenone was one of the compounds tested but was found not to prevent mold growth, making it unsuitable for hay storage
Furthermore, there is no predictable link between the chemical structure and other physicochemical parameters relevant in the cosmetic field, namely the toxicological acceptability of the substance, skin tolerance, stability, solubility and formulation properties, and odor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0442] The synergistic activity of mixtures of 4-isopropyl-3-methylphenol and α-bisabolol against Staphylococcus aureus and Staphylococcus epidermidis was determined.

[0443] In order to calculate the synergistic synergistic activity of the compound of formula (I) and other antimicrobial active substances, use Kull's equation 1 2

[0444] (I) SI=(C 混合物 ×P A ) / C A +(C 混合物 ×P B ) / C B

[0445] in

[0446] SI According to Kull 1),2) The synergy coefficient of

[0447] C A Substance A cell count

[0448] C B Substance B cell count

[0449] C 混合物 Cell number of mixture of substances A and B

[0450] P A The proportion of substance A in the mixture

[0451] P B The proportion of substance B in the mixture.

[0452] Antimicrobial activity was assessed by determining the minimum inhibitory concentration (MIC), which represents the lowest chemical concentration that inhibits visible growth of bacteria.

[0453] MIC values ​​are determined by preparing chemica...

preparation Embodiment

[0466] The invention is further illustrated by the following examples. if not otherwise indicated

[0467] "Mixture A according to the invention" refers to a 2:1 mixture of 4-isopropyl-3-methylphenol and α-bisabolol, "mixture B according to the invention" refers to 4-isopropyl-3-methylphenol 1:2 mixture of 3-methylphenol and α-bisabolol, "mixture C according to the invention" is a 1:1 mixture.

[0468] Table IA

[0469] Fragrance oil P1 (amount in % b.w.)

[0470]

[0471]

[0472] Table IB

[0473] Perfume oil P2 (amount in % b.w.)

[0474]

[0475]

[0476] Table IC

[0477] Fragrance oil P3 (amount in % b.w.)

[0478]

[0479]

[0480] table ID

[0481] Perfume oil P4 with aroma of white flowers (amount in % b.w.)

[0482]

[0483]

[0484] The aromatic oils P1, P2, P3 and P4 obtained in the above examples were individually processed in each case into the following formulations.

[0485] Table II

[0486] Liquid Soap, Clear (Consumption % b...

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PUM

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Abstract

Suggested is a synergistic antimicrobial mixture comprising p-thymol and alpha-bisabolol, which is particular useful for fighting S. aureus and S. epidermidis.

Description

[0001] field of invention [0002] The present invention belongs to the field of antimicrobial formulations for personal care, detergent and nutritional products and relates to new antimicrobial formulations and their use in various fields of consumer products. Background technique [0003] In the cosmetic and pharmaceutical and food industries there is a constant need for preparations with antimicrobial properties, especially for preserving perishable products such as cosmetics, pharmaceuticals or food, but also for the protection against possible adverse effects on the human or animal body direct cosmetic or therapeutic treatment of microorganisms. By way of example, mention may be made of microorganisms which cause body odour, acne, fungal diseases and the like. [0004] In the technical field involved, it is true that a large number of antimicrobially active compounds are already used, but the search for alternatives continues in order to enable targeted specific treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/08A01N49/00A01P1/00
CPCA01N31/08A01N49/00A01P1/00A61K8/34A61K8/347A61Q17/005A61Q15/00C11D3/2034C11D3/2037C11D3/48A23L3/349A01N43/40A23L3/34A61K8/35A61K8/345A23L3/3499A23V2002/00
Inventor I·迈耶M·佩萨罗
Owner SYMRISE GMBH & CO KG