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Medical dressing with antibacterial property and preparation method of medical dressing
Pending Publication Date: 2021-11-23
XIANGYA HOSPITAL CENT SOUTH UNIV
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[0003] Zhang Yiwen prepared a lignin / chitosan / PVA hydrogel medical dressing in the article "Preparation and Performance Research of Lignin-Based Wound Dressing". In this dressing, with the increase of lignin content, its hydrophilic However, the anionic groups in lignin will neutralize the cationic groups of chitosan, resulting in higher lignin content, lignin / shell Unsatisfactory antibacterial properties of polysaccharide / PVA hydrogel medical dressings
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Embodiment 1
[0021] A. 4g chitosan is dissolved in the acetic acid solution that 36mL volume concentration is 2%, obtain chitosan solution X after stirring;
[0022] B. Dissolve 8g of PVA in 32g of deionized water and stir at 90°C for 30min to obtain PVA solution Y;
[0023] C. Dissolve 3g of lignosulfonate in 7g of deionized water, stir well to obtain lignosulfonate solution Z;
[0024] D. disperse 0.33g nano-silver in 10g deionized water to form a nano-silver dispersion;
[0025] E. Take 10g of solutions X, Y, and Z respectively, mix and stir with the nano-metal dispersion in step D for 5 hours, pour into the mold, freeze at -18°C for 8 hours, then thaw at room temperature, repeat 5 times to obtain a hydrogel medical dressing .
Embodiment 2
[0027] A. 4g chitosan is dissolved in the acetic acid solution that 36mL volume concentration is 2%, obtain chitosan solution X after stirring;
[0028] B. Dissolve 8g of PVA in 32g of deionized water and stir at 90°C for 30min to obtain PVA solution Y;
[0029] C. Dissolve 3g of lignosulfonate in 7g of deionized water, stir well to obtain lignosulfonate solution Z;
[0030] D. disperse 0.29g nano-zinc in 10g deionized water to form a nano-zinc dispersion;
[0031] E. Take 10g of solutions X, Y, and Z respectively, mix and stir with the nano-metal dispersion in step D for 5 hours, pour into the mold, freeze at -18°C for 8 hours, then thaw at room temperature, repeat 5 times to obtain a hydrogel medical dressing .
Embodiment 3
[0033] A. 4g chitosan is dissolved in the acetic acid solution that 36mL volume concentration is 2%, obtain chitosan solution X after stirring;
[0034] B. Dissolve 8g of PVA in 32g of deionized water and stir at 90°C for 30min to obtain PVA solution Y;
[0035] C. Dissolve 3g of lignosulfonate in 7g of deionized water, stir well to obtain lignosulfonate solution Z;
[0036] D. disperse 0.62g nano-silver in 10g deionized water to form a nano-silver dispersion;
[0037] E. Take 10g of solutions X, Y, and Z respectively, mix and stir with the nano-metal dispersion in step D for 5 hours, pour into the mold, freeze at -18°C for 8 hours, then thaw at room temperature, repeat 5 times to obtain a hydrogel medical dressing .
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Abstract
The invention relates to a medical dressing with an antibacterial property and a preparation method of the medical dressing. In order to improve the antibacterial property of a lignin / chitosan / PVA hydrogel medical dressing in the prior art, antibacterial metal nanoparticles are doped into the hydrogel medical dressing. Research shows that along with the increase of the content of the antibacterial particles, the antibacterial property of the medical dressing can also be remarkably improved, and the antibacterial property of metal silver is more excellent than that of metalzinc. Moreover, under a certain condition, the two antibacterial metal particles can also play a synergistic interaction role, so that an unexpected antibacterial effect is achieved.
Description
technical field [0001] The invention relates to the field of medical dressings, in particular to a medical dressing with antibacterial properties and a preparation method thereof. Background technique [0002] Injuries to human skin can generally be divided into two categories: those with tissue defects and those without tissue defects. Medical dressings are medical products used for skin injuries. Traditional medical dressing (natural gauze) has the advantages of strong ability to absorb wound exudate and relatively simple production and processing process, but its permeability is too high, it is easy to dehydrate the early wound and deepen the wound, and it will cause mechanical damage again when it is replaced. Injury, and the risk of late bruise formation is increased due to the injury. When the exudate penetrates the full layer of gauze, microorganisms in the external environment can easily pass through, and there is a high risk of infection. In response to this proble...
Claims
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Application Information
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