Preparation method and application of photocuring dual-network hydrogel

Abstract

The invention relates to a preparation method of a photocuring dual-network hydrogel. The preparation method comprises the following steps: S1, dissolving: dissolving glycyrrhizic acid and glycyrrhizic acid derivatives in hot water to obtain single-network hydrogel (GA) with gel forming concentration of at least 2%; and S2, mixing: mixing the single-network hydrogel (GA) with a methacrylated silk fibroin aqueous solution, adding a photoinitiator, cooling to form first-network hydrogel, and performing ultraviolet irradiation to form the dual-network hydrogel (SF / GA). The invention aims to provide the preparation method of the photocuring dual-network hydrogel. The mechanical strength of the hydrogel can be remarkably enhanced, and the hydrogel can also have the functions of solubilizing and slowly releasing hydrophobic drugs.

Description

technical field [0001] The invention relates to the field of hydrogel materials, in particular to a preparation method and application of a light-cured double network hydrogel. Background technique [0002] Hydrogel is a three-dimensional material with cross-linked network structure, its water content exceeds 90%, and it has good biocompatibility, so it has attracted extensive attention in the field of biomedicine, especially in the field of tissue repair materials. However, due to its ultra-high water content, the hydrogel has weak mechanical properties, insoluble hydrophobic drugs, and explosive release of hydrophilic drugs, which limit the application of hydrogels. [0003] The invention provides a method for preparing a photocurable double network hydrogel, and the structure of the double network can significantly enhance the mechanical strength of the hydrogel. At the same time, the double-network structure hydrogel prepared by the invention has rich hydrophobic struct...

AI Technical Summary

Problems solved by technology

However, due to its ultra-high water content, the hydrogel has weak mechanical properties, insoluble hydrophobic drugs, and explosive release of hydrophilic drugs, which limits the application of hydrogels.

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