Supercharge Your Innovation With Domain-Expert AI Agents!

IGF1 receptor mediated bTiO2-based pancreatic cancer diagnosis and treatment nanoprobe construction method and performance verification method

A technology based on pancreatic cancer and nanoprobes, applied in the field of pancreatic cancer, can solve the problems of lack of blood supply, limited drug concentration in tumor tissue, high intratumoral tissue fluid pressure, etc., and achieve the effect of increasing permeability

Active Publication Date: 2021-12-17
THE AFFILIATED HOSPITAL OF MEDICAL SCHOOL NINGBO UNIV +1
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the unique tumor microenvironment of pancreatic cancer, including rich tumor stroma, poor blood supply, and high intratumoral interstitial fluid pressure, limits the nano drug delivery system to passively target the drug concentration in tumor tissue through EPR.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • IGF1 receptor mediated bTiO2-based pancreatic cancer diagnosis and treatment nanoprobe construction method and performance verification method
  • IGF1 receptor mediated bTiO2-based pancreatic cancer diagnosis and treatment nanoprobe construction method and performance verification method
  • IGF1 receptor mediated bTiO2-based pancreatic cancer diagnosis and treatment nanoprobe construction method and performance verification method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0085] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is some embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0086] Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the implementation manners in the present invention, all other ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses an IGF1 receptor mediated bTiO2-based pancreatic cancer diagnosis and treatment nanoprobe construction method and a performance verification method. The construction method of the IGF1 receptor mediated bTiO2-based pancreatic cancer diagnosis and treatment nanoprobe comprises the following steps of preparing bTiO2, synthesizing a bTiO2-Gd-COOH nano compound, coupling IGF1 polypeptide, and synthesizing a bTiO2-Gd-GEM nano probe and a bTiO2-Gd-IGF1-GEM nano probe. According to the performance verification method of the IGF1 receptor mediated bTiO2-based pancreatic cancer diagnosis and treatment nanoprobe, the characterization, the magnetic resonance performance, the photo-thermal performance, the drug release efficiency and the targeting performance of the bTiO2-Gd-IGF1-GEM nanoprobe are tested, and the cytotoxicity and the in-vitro photo-thermal chemotherapy synergistic treatment effect are tested. According to the method, the construction of the IGF1 receptor-mediated bTiO2-based pancreatic cancer diagnosis and treatment nano-probe is simply and conveniently achieved, the IGF1 receptor-mediated bTiO2-based pancreatic cancer diagnosis and treatment nano-probe can be adopted as the pancreatic cancer matrix and cell targeting molecular marker so as to increase the matrix and vascular permeability, and the performance of the probe can be effectively verified.

Description

technical field [0001] The invention relates to the technical field of pancreatic cancer, in particular to IGF1 receptor-mediated bTiO 2 A method for constructing nano-probes for the diagnosis and treatment of pancreatic cancer, and the present invention also relates to the IGF1 receptor-mediated bTiO 2 Performance verification method of nanoprobes for diagnosis and treatment of pancreatic cancer. Background technique [0002] The main imaging methods currently used for the diagnosis of pancreatic cancer include ultrasound, computed tomography (CT), magnetic resonance imaging (magnetic resonance imaging, MRI), and positron emission tomography-computed tomography (PET). -CT) etc. These imaging methods still have great difficulties in the early diagnosis of pancreatic cancer. Ultrasound examination is convenient and economical, but it is easily affected by gas in the gastrointestinal tract. At the same time, due to the low specificity and sensitivity of ultrasound, the dete...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/14A61K49/12A61K47/69A61K41/00A61K47/64A61K31/7068A61P35/00B82Y5/00B82Y15/00B82Y40/00G01N1/30G01N21/31G01N21/33G01N21/71
CPCA61K41/0052A61K47/642A61K49/1824A61K49/14A61P35/00B82Y5/00B82Y15/00B82Y40/00A61K31/7068A61K47/6923A61K49/126G01N21/718G01N21/314G01N21/33G01N1/30A61K2300/00
Inventor 汪建华徐开蔚吴爱国任文智
Owner THE AFFILIATED HOSPITAL OF MEDICAL SCHOOL NINGBO UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com