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Organ preservation solution

A technology of organ preservation solution and simulant, which is applied in the field of organ transplantation, can solve the problems of the need to expand advanced preservation, the short time, hinder the widespread popularization and clinical application of organ transplantation technology, etc., and achieve the effect of improving quality and slowing down decomposition.

Active Publication Date: 2021-12-24
THE FIRST PEOPLES HOSPITAL OF FOSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the shortage of organs is still the main problem hindering the widespread promotion and clinical application of organ transplantation technology. The ratio between organ waiters and donors in my country is about 30:1
And these organ donors are at risk of ischemic injury and reperfusion injury, expanding the need for advanced preservation
Static cold preservation is the most commonly used clinical organ preservation technique in the field of transplantation. The purpose is to limit the consumption of adenosine triphosphate (ATP) and inhibit the activity of cellular enzymes, reducing the degradation of cells through phospholipid hydrolysis. Tissues or organs have a shorter time, which is not conducive to the preservation of cells, tissues and organs

Method used

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  • Organ preservation solution
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Examples

Experimental program
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Effect test

Embodiment 1

[0024] An organ preservation solution, comprising components at the following concentrations: mannitol 10.93g / L; lactobionic acid 28.664g / L; glutamic acid 2.942g / L; sodium hydroxide 4g / L; calcium chloride 0.037g / L; Potassium chloride 1.118g / L; magnesium chloride 2.642g / L; histidine 4.65g / L; glutathione 0.921L; hydrated cobalt chloride 0.39mol / mL. The osmotic pressure is 320 mOsmol / kg.

Embodiment 2

[0026] An organ preservation solution, comprising components at the following concentrations: mannitol 10.93g / L; lactobionic acid 28.664g / L; glutamic acid 2.942g / L; sodium hydroxide 4g / L; calcium chloride 0.037g / L; Potassium chloride 1.118g / L; magnesium chloride 2.642g / L; histidine 4.65g / L; glutathione 0.921L; hydrated cobalt chloride 0.78mol / mL. The osmotic pressure is 320 mOsmol / kg.

Embodiment 3

[0028] An organ preservation solution, comprising components at the following concentrations: mannitol 10.93g / L; lactobionic acid 28.664g / L; glutamic acid 2.942g / L; sodium hydroxide 4g / L; calcium chloride 0.037g / L; Potassium chloride 1.118g / L; magnesium chloride 2.642g / L; histidine 4.65g / L; glutathione 0.921L; hydrated cobalt chloride 1.56mol / mL. The osmotic pressure is 320 mOsmol / kg.

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Abstract

The invention discloses an organ preservation solution comprising the following components by concentration: 10-12 g / L mannitol, 25-30 g / L of lactobionic acid, 2-3 g / L of glutamic acid, 3-5 g / L of sodium hydroxide, 0.02-0.05 g / L of calcium chloride, 1-2 g / L of potassium chloride, 2-3 g / L of magnesium chloride, 4-5 g / L of histidine, 0.5-1 g / L of glutathione, and 0.39-1000 [mu]mol / mL of an anoxic simulation agent. The organ preservation solution can effectively prolong the static refrigeration time of cells, tissues or organs.

Description

technical field [0001] The invention belongs to the technical field of organ transplantation, in particular to an organ preservation solution. Background technique [0002] Organ transplantation is a life-saving treatment commonly used in end-stage diseases, primary and fulminant organ failure, among others. However, the shortage of organs is still the main problem hindering the widespread promotion and clinical application of organ transplantation technology. The ratio between organ waiters and donors in my country is about 30:1. And these organ donors are at risk of suffering ischemic injury and reperfusion injury, expanding the need for advanced preservation. Static cold preservation is the most commonly used technique for clinical organ preservation in the field of transplantation. The purpose is to limit the consumption of adenosine triphosphate (ATP) and inhibit the activity of cellular enzymes, reducing the degradation of cells through phospholipid hydrolysis. The t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/021A01N1/0221A01N1/0226
Inventor 何惠仪陈焕伟孔令枝欧骏杰
Owner THE FIRST PEOPLES HOSPITAL OF FOSHAN