Traditional Chinese medicine composition for treating androgenetic alopecia and preparation method and application thereof

A technology of androgenicity and composition, which is applied in the field of traditional Chinese medicine composition for the treatment of androgenetic alopecia and its preparation, can solve the problems of unclear mechanism of action and satisfaction of curative effect patients, achieve good therapeutic effect and improve skin lesions Tissue shape, effect of promoting hair growth

Active Publication Date: 2021-12-31
广州市皮肤病防治所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Minoxidil is a recognized topical drug for the treatment of androgenetic alopecia. Its mechanism of action is still unclear. During clinical application, contact dermatitis, skin irritation, dizziness and tachycardia can be observed in a considerable number of patients. and other adverse reactions, and hair loss may continue to progress aft

Method used

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  • Traditional Chinese medicine composition for treating androgenetic alopecia and preparation method and application thereof
  • Traditional Chinese medicine composition for treating androgenetic alopecia and preparation method and application thereof
  • Traditional Chinese medicine composition for treating androgenetic alopecia and preparation method and application thereof

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Effect test

Embodiment 1

[0032] The lotion for the treatment of androgenetic alopecia of the present embodiment, its crude drug is composed of: Vitex 30g, Arborvitae 30g, Phellodendron 15g, Eclipta 30g, Fructus Lycii 30g, Rhizoma Chuanxiong 20g, Angelica dahurica 15g, Psoraleae 15g.

[0033] Exemplarily, its preparation method comprises the following steps:

[0034] Mix the raw materials according to the ratio, add 10 times the weight of the raw materials and decoct them for 3 times.

[0035] In addition, in order to obtain the lotion for treating androgenetic alopecia of the present invention, it can be prepared according to the methods in the prior art, and will not be listed here.

Embodiment 2

[0037] The ointment of the present embodiment for the treatment of androgenetic alopecia, its raw material consists of: Vitex 30g, Arborvitae 30g, Phellodendron 15g, Eclipta 30g, Fructus Lycii 30g, Rhizoma Chuanxiong 20g, Angelica dahurica 15g, Psoraleae 15g.

[0038] Exemplarily, its preparation method comprises the following steps:

[0039] Mix the raw materials according to the proportion, add 10 times the weight of the raw materials and decoct them for 3 times, boil them with strong fire, then decoct them with slow fire for 40 minutes, combine the decoctions with water, filter, and concentrate the filtrate under reduced pressure to a thick liquid with a relative density of 1.30 at 25°C. Ointment, that is.

[0040] In addition, in order to obtain the ointment for treating androgenetic alopecia of the present invention, it can be prepared according to the methods in the prior art, and will not be listed here.

[0041] Next, the testosterone propionate-induced mouse model o...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating androgenetic alopecia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the raw material medicines in parts by weight: 10-30 parts of fructus viticis, 15-30 parts of cacumen platycladi, 10-15 parts of cortex phellodendri, 15-30 parts of herba ecliptae, 20-30 parts of fructus lycii, 10-20 parts of ligusticum wallichii, 8-15 parts of radix angelicae and 5-15 parts of fructus psoraleae. The preparation method and application of the traditional Chinese medicine composition for treating androgenetic alopecia are further provided. Testosterone propionate induced mouse androgenic alopecia model animal experiments show that the traditional Chinese medicine composition can promote the hair growth of a testosterone propionate induced androgenic alopecia mouse, improve the tissue form of skin lesion and inhibit the synthesis of type II 5 alpha reductase in the skin lesion. Therefore, the traditional Chinese medicine composition has a relatively good treatment effect on androgenetic alopecia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating androgenetic alopecia, a preparation method and application thereof. Background technique [0002] Androgenetic alopecia (AGA), also known as male pattern alopecia or seborrheic alopecia, is one of the common types of hair loss. AGA is an autosomal dominant genetic disease, and the androgen-dependent miniaturization of hair follicles caused by the elevated local concentration of dihydrotestosterone in the scalp is one of the important pathogenic factors. [0003] Drug therapy is one of the important means for the treatment of androgenetic alopecia. At present, finasteride and minoxidil are the mainstream drugs for the treatment of androgenetic alopecia. Finasteride is a 5α-reductase inhibitor that inhibits the conversion of testosterone to the more active dihydrotestosterone. However, two-...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P17/10
CPCA61K36/85A61K36/14A61K36/756A61K36/28A61K36/815A61K36/236A61K36/232A61K36/487A61P17/10A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 李振洁卢月黄久遂朱慧兰
Owner 广州市皮肤病防治所
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