Traditional Chinese medicine composition for treating androgenetic alopecia and preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating androgenetic alopecia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the raw material medicines in parts by weight: 10-30 parts of fructus viticis, 15-30 parts of cacumen platycladi, 10-15 parts of cortex phellodendri, 15-30 parts of herba ecliptae, 20-30 parts of fructus lycii, 10-20 parts of ligusticum wallichii, 8-15 parts of radix angelicae and 5-15 parts of fructus psoraleae. The preparation method and application of the traditional Chinese medicine composition for treating androgenetic alopecia are further provided. Testosterone propionate induced mouse androgenic alopecia model animal experiments show that the traditional Chinese medicine composition can promote the hair growth of a testosterone propionate induced androgenic alopecia mouse, improve the tissue form of skin lesion and inhibit the synthesis of type II 5 alpha reductase in the skin lesion. Therefore, the traditional Chinese medicine composition has a relatively good treatment effect on androgenetic alopecia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating androgenetic alopecia, a preparation method and application thereof. Background technique [0002] Androgenetic alopecia (AGA), also known as male pattern alopecia or seborrheic alopecia, is one of the common types of hair loss. AGA is an autosomal dominant genetic disease, and the androgen-dependent miniaturization of hair follicles caused by the elevated local concentration of dihydrotestosterone in the scalp is one of the important pathogenic factors. [0003] Drug therapy is one of the important means for the treatment of androgenetic alopecia. At present, finasteride and minoxidil are the mainstream drugs for the treatment of androgenetic alopecia. Finasteride is a 5α-reductase inhibitor that inhibits the conversion of testosterone to the more active dihydrotestosterone. However, two-...

AI Technical Summary

Problems solved by technology

Minoxidil is a recognized topical drug for the treatment of androgenetic alopecia. Its mechanism of action is still unclear. During clinical application, contact dermatitis, skin irritation, dizziness and tachycardia can be observed in a considerable number of patients. and other adverse reactions, and hair loss may continue to progress after stopping the drug

[0004] Traditional Chinese medicine is easy to be accepted by consumers due to its low toxic and side effects and good safety. For androgenetic alopecia, there are some traditional Chinese medicine external preparations on the market. Although they have certain effects, their curative effect still cannot satisfy patients.

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