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Rhodococcus ruber immunopotentiator and application thereof in vaccine for pigs

A technology of Rhodococcus rubrum and immune enhancer, applied in veterinary vaccines, vaccines, bacteria and other directions, can solve the problem of poor immune protection effect, and achieve the effect of long duration of antibodies, enhanced immunogenicity and high safety

Pending Publication Date: 2022-01-28
广东渔跃生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are immunopotentiators used in porcine vaccines in the prior art, the immunopotentiators used in porcine vaccines have problems such as poor immune protection effect

Method used

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  • Rhodococcus ruber immunopotentiator and application thereof in vaccine for pigs
  • Rhodococcus ruber immunopotentiator and application thereof in vaccine for pigs

Examples

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Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, a kind of Rhodococcus rubrum immunopotentiator

[0039] Said Rhodococcus rubrum immunopotentiator comprises the culture of Rhodococcus rubrum, chitosan oligosaccharide and Yunzhi polysaccharide; the mass ratio of the culture of Rhodococcus rubrum, chitosan oligosaccharide and Yunzhi polysaccharide is 8:4:1 .

[0040] The preparation method of the culture of described Rhodococcus rubrum is: place Rhodococcus rubrum in the 30L fermenter tank that adds culture medium and cultivate 24h, the condition of cultivation is: stirring speed 200r / min, ventilation rate 1:1.0, inoculation Amount of 6%, liquid filling amount is 70% of the tank volume, temperature 30 ℃, high temperature and high pressure inactivation, the specific operation of the high temperature and high pressure inactivation is 121 ℃, 101kPa, treatment for 20min, to obtain final product;

[0041] The medium includes the following components and their mass percentages: 1% glucose, 2% yeast powder, 0.01...

Embodiment 2

[0042] Embodiment 2, a kind of Rhodococcus rubrum immunopotentiator

[0043] The Rhodococcus rubrum immunopotentiator comprises the culture of Rhodococcus rubrum, chitosan oligosaccharide and Yunzhi polysaccharide; the mass ratio of the culture of Rhodococcus rubrum, chitosan oligosaccharide and Yunzhi polysaccharide is 10:3:1 .

[0044] The preparation method of the culture of described Rhodococcus rubrum is: place Rhodococcus rubrum in the 30L fermenter tank that adds culture medium and cultivate 36h, the condition of cultivation is: stirring speed 200r / min, ventilation rate 1:1.0, inoculation Amount of 6%, liquid filling amount is 70% of the tank volume, temperature 30 ℃, high temperature and high pressure inactivation, the specific operation of the high temperature and high pressure inactivation is 121 ℃, 101kPa, treatment for 20min, to obtain final product;

[0045]The medium includes the following components and their mass percentages: 2% glucose, 4% yeast powder, 0.02%...

Embodiment 3

[0046] Embodiment 3, a kind of Rhodococcus rubrum immunopotentiator

[0047] The rhodococcus immunopotentiator comprises the culture of rhodococcus rubrum, chitosan oligosaccharide and versicolor polysaccharide; the mass ratio of the culture of rhodococcus rubrum, chitosan oligosaccharide and versicolor polysaccharide is 9:3:1 .

[0048] The preparation method of the culture of described Rhodococcus rubrum is: place Rhodococcus rubrum in the 30L fermenter tank that adds culture medium and cultivate 30h, the condition of cultivation is: stirring speed 200r / min, ventilation rate 1:1.0, inoculation Amount of 6%, liquid filling amount is 70% of the tank volume, temperature 30 ℃, high temperature and high pressure inactivation, the specific operation of the high temperature and high pressure inactivation is 121 ℃, 101kPa, treatment for 20min, to obtain final product;

[0049] The medium includes the following components and their mass percentages: 1% glucose, 3% yeast powder, 0.01...

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Abstract

The invention belongs to the technical field of biological products for pigs, and relates to a rhodococcus ruber immunopotentiator and application thereof in vaccine for pigs. The rhodococcus ruber immunopotentiator comprises a rhodococcus ruber culture, chitosan oligosaccharide and coriolus versicolor polysaccharide; the mass ratio of the rhodococcus ruber culture to the chitosan oligosaccharide to the coriolus versicolor polysaccharide is (8-10): (3-4): 1. An oil emulsion inactivated vaccine for pigs prepared by adopting the immunopotentiator is safe, efficient, long in antibody duration and good in immune protection effect.

Description

technical field [0001] The invention belongs to the technical field of biological products for pigs, and in particular relates to a rhodococcus immunopotentiator and its application in pig vaccines. Background technique [0002] In recent years, the pig industry is facing more complex and changeable pig diseases than before. Not only are there more and more types of diseases, but also it is becoming more and more difficult to prevent and control. This phenomenon is mainly caused by the introduction of various foreign diseases and the mutation and renewal of viruses. With the prevalence of infectious viral diseases such as porcine blue ear disease, porcine circular type 2, swine fever, porcine pseudorabies and other diseases, new vaccines on the market have emerged as the times require. At present, the incidence of immunosuppressive diseases of various diseases in China is generally increasing, causing serious harm. In this situation, the prevention and control of swine dis...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K39/12A61P31/14C12N1/20C12R1/01
CPCA61K39/39A61K39/12A61P31/14C12N1/20A61K2039/55583A61K2039/55594A61K2039/552A61K2039/575
Inventor 严悌昆张毓金陈珊王文勇黄淑芬
Owner 广东渔跃生物技术有限公司
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