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Flurbiprofen gel, gel plaster preparation process and coating machine

A flurbiprofen and coating machine technology, applied in the directions of ointment delivery, organic active ingredients, medical preparations with non-active ingredients, etc. problems such as uneven adhesive coating, to achieve the effect of easy cleaning or maintenance, easy maintenance and cleaning, and improving the scope of application

Pending Publication Date: 2022-03-01
杭州上禾健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The quality of the flurbiprofen gel patch is related to the transdermal release and adhesion ability of the gel, and the transdermal release ability and adhesion ability are related to the components contained in the flurbiprofen gel and the flurbiprofen gel. Flurbiprofen gel plaster is related to the coating quality in the preparation process. The excessive viscosity of flurbiprofen gel makes it easy to attach gel to the cutting part of the equipment during the coating process, which affects the normal production of the coating machine equipment. Inhomogeneous coating on the nonwoven resulting in reduced quality of the gel patch

Method used

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  • Flurbiprofen gel, gel plaster preparation process and coating machine
  • Flurbiprofen gel, gel plaster preparation process and coating machine
  • Flurbiprofen gel, gel plaster preparation process and coating machine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1 of the present application discloses a flurbiprofen gel, which comprises the following components by weight:

[0077] Flurbiprofen 0.3g, sodium polyacrylate 6g, glycerin 30g, purified water 46.05g, gelatin 4g, transdermal enhancer 1.3g, emulsifier 0.65g, polyvinyl alcohol 3g, polyacrylic acid 3g, sodium carboxymethylcellulose 3g, 0.2g of crosslinking agent, 1g of pH regulator, 0.3g of crosslinking regulator, and 1.2g of filler.

[0078] Wherein, 0.3 g of menthol, 0.5 g of crotamiton and 0.5 g of isopropyl myristate are selected as the transdermal accelerator.

[0079] The emulsifiers are Tween-800.6g and Span-830.05g.

[0080] The cross-linking agent is aluminum glycol.

[0081] The pH regulator is tartaric acid.

[0082] Disodium edetate is selected as the cross-linking regulator.

[0083] The fillers are 1g of kaolin and 0.2g of titanium dioxide.

[0084] The preparation method of flurbiprofen gel patch is as follows:

[0085] S1: Divide the total puri...

Embodiment 2-10

[0124] The difference between Examples 2-4 and Example 1 is that the dosage of each component in the flurbiprofen gel is different, as shown in Table 1.

[0125] Content of each component in table 1 flurbiprofen gel

[0126]

[0127] The difference between Examples 5-13 and Example 1 is that the amounts of gelatin, polyvinyl alcohol, polyacrylic acid and sodium carboxymethylcellulose in the flurbiprofen gel are different, as shown in Table 2.

[0128] The consumption of each component in table 2 flurbiprofen gel

[0129]

[0130]

[0131] The difference between Examples 14-20 and Example 1 is that the control of each parameter in the preparation process of the flurbiprofen gel patch is different, as shown in Table 3.

[0132] Each parameter in the preparation process of table 3 flurbiprofen gel patch

[0133] Example Solution A holding temperature (°C) Solution B holding temperature (°C) Solution C holding temperature (°C) Example 14 10 35 35...

Embodiment 20

[0134] The difference between Example 20 and Example 1 is that in the preparation process of flurbiprofen gel plaster, step S5 is to combine crosslinking agent, crosslinking regulator, filler, carboxymethylcellulose, solution A, solution C and Solution D was simultaneously added to a stirring mixer for stirring, and the stirring speed was controlled at 150 rpm for 40 minutes at high speed.

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PUM

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Abstract

The invention relates to the field of dressings, and particularly discloses flurbiprofen gel, a gel plaster preparation process and a coating machine. The flurbiprofen gel is mainly prepared from 0.1 to 0.8 part of flurbiprofen and 1 to 8 parts of polyacrylic acid; 1-8 parts of polyvinyl alcohol and 1-8 parts of sodium carboxymethyl cellulose; the preparation method of the gel plaster mainly comprises the following steps: respectively compounding to obtain a solution A, a solution C and a solution D, maintaining a certain temperature, finally mixing to obtain gel, and coating, stamping and cutting the gel to obtain the gel plaster. The coating machine mainly comprises a rack, and a feeding device, a stamping device and a discharging device are sequentially arranged on the rack in the conveying direction of the gel plaster. The device has the effects of improving the production quality of the gel plaster and the stability of the production quality.

Description

technical field [0001] The application relates to the field of dressings, more specifically, it relates to a flurbiprofen gel, a gel plaster preparation process and a coating machine. Background technique [0002] Flurbiprofen is a non-steroidal anti-inflammatory drug. Because flurbiprofen is more irritating to the intestinal tract, it is usually administered to the pain site in the form of a gel patch. [0003] Flurbiprofen gel plaster usually uses non-woven fabric as the backing layer, and then the drug is coated on the surface of the backing layer by coating, and then covered with a protective film for protection. [0004] The quality of the flurbiprofen gel patch is related to the transdermal release and adhesion ability of the gel, and the transdermal release ability and adhesion ability are related to the components contained in the flurbiprofen gel and the flurbiprofen gel. Flurbiprofen gel plaster is related to the coating quality in the preparation process. The ex...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/06A61K31/192A61K47/10A61K47/32A61K47/38A61K47/42A61P29/00A61J3/00
CPCA61K31/192A61K9/06A61K9/7061A61K47/10A61K47/42A61K47/38A61P29/00A61J3/00
Inventor 王宝金张岩李慧杰
Owner 杭州上禾健康科技有限公司