Miniature tablet as well as preparation method and preparation thereof
A technology of micro-tablets and micro-tablets, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., to achieve the effects of small size, reduced complexity, and reduced various risks
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Embodiment 1
[0050] A miniature tablet, the composition of which is as follows:
[0051] Table 1 Composition of Example 1
[0052]
[0053]
[0054] The preparation method of described mini-tablet, comprises the following steps:
[0055] (1) Micronize the active ingredient and control the particle size to D 90 =9.3μm, after using water to disperse, the atomization system sprays into the filler, and the droplet size is controlled to be D 90 =87.6μm; Spray-dried below 40°C, mixed evenly with disintegrating agent and lubricant to make particle size D 90 = 143.1 μm particles;
[0056] (2) The granules are made into microtablets with a diameter of 3 mm and a tablet weight of 20 mg.
Embodiment 2
[0058] A miniature tablet, the composition of which is as follows:
[0059] Table 2 Composition of Example 2
[0060] components Specific ingredients parts by weight active ingredient Oseltamivir Phosphate 40 filler Microcrystalline cellulose, erythritol, xylan and wheat starch with a mass ratio of 6:1:2:5 30 disintegrant Soybean polysaccharide, glucuronic acid and alginic acid with a mass ratio of 5:1:3 3 Glidant Sodium stearyl fumarate 4
[0061] The preparation method of described mini-tablet, comprises the following steps:
[0062] (1) Micronize the active ingredient and control the particle size to D 90 =43.6μm, after using water to disperse, the atomization system sprays into the filler, and the particle size of the droplets is controlled to be D 90 =378.5μm; Spray-dried below 25°C, mixed evenly with disintegrating agent and glidant to make particle size D 90 = 223.7 μm particles;
[0063] (2) The granules are made int...
Embodiment 3
[0065] A miniature tablet, the composition of which is as follows:
[0066] Table 3 Composition of Embodiment 3
[0067] components Specific ingredients parts by weight active ingredient Digoxin 0.25 filler Microcrystalline cellulose, erythritol, xylan and tapioca flour in a mass ratio of 2:1:1:3 30 disintegrant A mixture of mannose and alginic acid with a mass ratio of 3:2 8 lubricant magnesium aluminum silicate 10
[0068] The preparation method of described mini-tablet, comprises the following steps:
[0069] (1) Micronize the active ingredient and control the particle size to D 90 =17.8μm, after using water to disperse, the atomization system sprays into the filler, and the droplet size is controlled to be D 90 =453.9μm; Spray-dried below 60°C, mixed evenly with disintegrant and lubricant to make particle size D 90 = 101.6 μm particles;
[0070] (2) The granules are made into microtablets with a diameter of 3 mm and a ta...
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