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Method for classifying samples based on determination of FGFR

A FGFR2, sample technology, applied in biochemical equipment and methods, analytical materials, biomaterial analysis, etc., can solve the problem of low benefit for patients with luminal I tumors

Pending Publication Date: 2022-05-06
STRETIFAER MOLEKYULAR PATOLODZHI GMBKH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gene expression studies suggest less benefit of atezolizumab in patients with luminal type I tumors that can be enriched for FGFR3 mutations

Method used

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  • Method for classifying samples based on determination of FGFR
  • Method for classifying samples based on determination of FGFR
  • Method for classifying samples based on determination of FGFR

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Embodiment

[0232] While the invention has been illustrated and described in detail in the drawings and foregoing description, such illustration and description are to be considered illustrative or exemplary and not restrictive; the invention is not limited to the disclosed embodiments . Other variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing the claimed invention, from a study of the drawings, the disclosure, and the appended claims. In the claims, the word "comprising" does not exclude other elements or steps, and the non-limiting articles "a (a)" or "an (an)" do not exclude a plurality. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage. Any reference signs in the claims should not be construed as limiting the scope.

[0233] All amino acid sequences disclosed herein are shown from N-terminus to C-terminu...

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Abstract

The present invention relates to a method of classifying a sample of a patient suffering from or at risk of developing urothelial carcinoma or bladder cancer, the method comprises the steps of: a) determining the presence or absence of an alteration in the FGFR gene and / or the expression level of at least one gene encoding the FGFR1, FGFR2, FGFR3 or FGFR4 receptor in the sample from the patient, and b) classifying the sample of the patient resulting from step a) into one of at least two classifications, the classification includes a good prognosis and a poor prognosis for treatment with an anti-cancer agent.

Description

technical field [0001] This application relates to the field of molecular diagnostics. Background technique [0002] Urothelial carcinoma (UC) is one of the 10 most common malignancies worldwide, with nearly 386,000 new cases and nearly 150,200 deaths / year, characterized by high rates of recurrence and progression. For decades, the only treatment option for metastatic UC was platinum-based chemotherapy, which was associated with a low 5-year overall survival rate of ≤15% and a poor prognosis for patients who failed standard chemotherapy regimens. [0003] Immunotherapy represents an emerging concept of anticancer treatment. In particular, antibodies targeting CTLA4, PD-1, or PD-L1 have had surprising therapeutic success, for example in patients with metastatic melanoma, which is considered a highly immunogenic tumor. In addition, antibodies, such as Nivolumab, have been successfully used to treat systemic advanced non-small cell lung cancer and renal cell carcinoma. The s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574C12Q1/6886
CPCG01N33/574G01N2800/50G01N2800/52G01N2800/34G01N2333/71C12Q1/6886C12Q2600/156C12Q2600/118C12Q1/686C12Q2600/106C12Q2600/158C12Q2600/16
Inventor R·M·维尔茨P·埃尔本R·施特尔M·埃克施泰因
Owner STRETIFAER MOLEKYULAR PATOLODZHI GMBKH
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