Temperature-sensitive debonding wet tissue adhesion hydrogel and preparation method thereof
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A hydrogel and debonding technology, which is applied in the directions of pharmaceutical formulation, surgery, drug delivery, etc., can solve problems such as difficult and difficult to peel off practical applications, and achieve the effect of short molding time, simple process and simple debonding process
Active Publication Date: 2022-06-21
FUJIAN NORMAL UNIV
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Problems solved by technology
Mussel-like adhesive hydrogel can exhibit excellent wet tissue adhesion, but it is difficult to peel off after use, which brings difficulties to practical application
Method used
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Embodiment 1
[0029] A preparation method of a temperature-sensitive and debonded wet tissue-adhering hydrogel, comprising the following steps:
[0030] 1. Dissolve 1.4g N-isopropylacrylamide, 0.6g acrylamide, 0.02g aminoethyl starch and 0.05g calcium chloride in 1g water;
[0031] 2. Add 0.02g urushiol, 0.002g crosslinking agent N,N'-methylenebisacrylamide and 0.006g photoinitiator 2,4,6-(trimethylbenzoyl) to the solution obtained in step 1 Diphenylphosphine oxide, stir to dissolve;
[0032] 3. Pour the solution obtained in step 2 into a polytetrafluoroethylene mold, and cure under 365 nm ultraviolet light for 60 minutes to obtain a temperature-sensitive and debonded tissue-adhesive hydrogel.
Embodiment 2
[0034] A preparation method of a temperature-sensitive and debonded wet tissue-adhering hydrogel, comprising the following steps:
[0035] 1. Dissolve 1.4g N-isopropylacrylamide, 0.6g acrylamide, 0.02g gelatin and 0.05g calcium chloride in 1g water;
[0036] 2. Add 0.02g urushiol, 0.004g crosslinking agent N,N'-methylenebisacrylamide and 0.008g photoinitiator 2,4,6-(trimethylbenzoyl) to the solution obtained in step 1 Diphenylphosphine oxide, stir to dissolve;
[0037] 3. Pour the solution obtained in step 2 into a mold, and cure under 365 nm ultraviolet light for 60 minutes to obtain a temperature-sensitive debonded tissue-adhesive hydrogel.
Embodiment 3
[0039] A preparation method of a temperature-sensitive and debonded wet tissue-adhering hydrogel, comprising the following steps:
[0040] 1. Dissolve 1.6g N-isopropylacrylamide, 0.4g acrylamide, 0.02g aminoethyl starch and 0.01g calcium chloride in 1g water;
[0041] 2. Add 0.02g urushiol, 0.004g crosslinking agent N,N'-methylenebisacrylamide and 0.008g photoinitiator 2,4,6-(trimethylbenzoyl) to the solution obtained in step 1 Diphenylphosphine oxide, stir to dissolve;
[0042] 3. Pour the solution obtained in step 2 into a mold, and cure under 365 nm ultraviolet light for 120 minutes to obtain a temperature-sensitive and debonded tissue-adhesive hydrogel.
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Abstract
The invention discloses a temperature-sensitive debonding wet tissue adhesion hydrogel and a preparation method thereof, and the preparation method comprises the following steps: S1, dissolving N-isopropylacrylamide, acrylamide, amino-containing biomacromolecules and calcium chloride in water to obtain a solution a; s2, urushiol, a cross-linking agent and a photoinitiator are added into the solution a and stirred to be dissolved, and a solution b is obtained; s3, the solution b is poured into a mold and cured under ultraviolet irradiation, and the temperature-sensitive debonding wet tissue adhesion hydrogel is obtained. The preparation method has the advantages that the preparation process of the wet tissue adhesion hydrogel is simple, and the forming time is short; the hydrogel can be quickly adhered to wet biological tissues; the hydrogel has high adhesion performance with biological tissues; the hydrogel can realize thermo-sensitive on-demand stripping only by normal-temperature water treatment; when the hydrogel is debonded, the operation is simple, and the debonding process is harmless to organisms; the wet tissue adhesion hydrogel can be used for closing wounds, blocking and stopping bleeding, and treating and curing animals in water.
Description
technical field [0001] The invention belongs to the technical field of preparation of tissue adhesive, in particular to a temperature-sensitive debonding wet tissue adhesion hydrogel and a preparation method thereof. Background technique [0002] In daily life, people experience various traumas, which are mainly skin damage, visceral rupture and so on. The most commonly used methods for treating wounds are suturing and stapling. Using these mechanical methods to treat wounds not only brings additional pain to the patient, but also is not easy to disassemble later. To reduce pain from mechanical methods, tissue glue is a good choice. Cyanoacrylate is a commonly used tissue adhesive that can form a solid-phase interface at tissue wounds to bond damaged tissue. However, its poor adhesion on wet tissues and the release of biotoxic cyanoacetates during degradation limit its use. With the increasing pursuit of a better life, modern medicine requires that the pain of the patient...
Claims
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