Ureteral stent tube based on bacterial cellulose composite coating and preparation method of ureteral stent tube
A ureteral stent tube, bacterial cellulose technology, applied in catheters, drug delivery, pharmaceutical formulations and other directions, can solve problems such as debris safety problems, and achieve the effects of avoiding safety problems, good practical significance, and good overall performance
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Embodiment 1
[0043] A preparation method of a ureteral stent tube based on bacterial cellulose composite coating, the specific steps are as follows:
[0044] (1) Combine the fermentation strain (Acetobacter xylinum) with the fermentation broth (each 100ml fermentation broth contains 5g glucose, 1g peptone, 1g yeast extract, 0.5g citric acid, 0.2g sodium dihydrogen phosphate, 3g magnesium sulfate, 3g Sodium alginate and the remaining amount of water) were evenly mixed, put into a hollow tubular fermentation device, and purified after 5 days of fermentation (meaning that the fermentation product was soaked in a sodium hydroxide solution with a mass concentration of 3wt%, at a temperature of 100°C Keep it for 3 hours under the same conditions, and then wash with water until the pH value is 7.0) to obtain the hollow tubular bacterial cellulose membrane III; wherein, the density of the fermentation strain added to the fermentation broth is 10 10 pcs / ml; the hollow tubular fermentation device is...
Embodiment 2
[0055] A method for preparing a ureteral stent tube based on bacterial cellulose composite coating, the specific steps are as follows:
[0056] (1) Combine the fermentation strain (Rhizobia) with the fermentation broth (each 100ml fermentation broth contains 5g glucose, 1g peptone, 1g yeast extract, 0.5g citric acid, 0.2g sodium dihydrogen phosphate, 3g magnesium sulfate, 3g seaweed Sodium and the remaining amount of water) were evenly mixed, put into a hollow tubular fermentation device, and purified after 5 days of fermentation (meaning that the fermentation product was soaked in a sodium hydroxide solution with a mass concentration of 4 wt %, at a temperature of 80° C. Condition for 3 hours, and then washed with water to pH 7.0) to obtain hollow tubular bacterial cellulose membrane III; wherein, the density of the fermentation strains added to the fermentation broth is 5 × 10 10 pcs / ml; the hollow tubular fermentation device is a double-layer jacketed tube, and the inner la...
Embodiment 3
[0062] A method for preparing a ureteral stent tube based on bacterial cellulose composite coating, the specific steps are as follows:
[0063] (1) The fermented strain (the ratio of the number of the two strains is 1:1) with the fermentation strain (each 100ml of the fermentation medium contains 10g of glucose, 2g of peptone, 2g of yeast extract, 1g of lemon) acid, 0.8g of sodium dihydrogen phosphate, 3.4g of magnesium sulfate, 3g of sodium alginate and the balance of water) were evenly mixed, put into a hollow tubular fermentation device, and purified after 6 days of fermentation (meaning that the fermentation product was soaked to a mass concentration 5 wt% sodium hydroxide solution, kept at 70°C for 6 hours, and then washed with water to pH 7.0) to obtain hollow tubular bacterial cellulose membrane III; wherein, the fermentation broth was added with fermented bacteria Density is 8×10 10 pcs / ml; the hollow tubular fermentation device is a double-layer jacketed tube, and th...
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