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Chewable tablet containing astaxanthin nanoparticles and preparation method thereof

A technology of nanoparticles and astaxanthin, which is applied in medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations with non-active ingredients, etc., can solve the problems of poor water solubility and poor bioavailability, and achieve low processing costs , Stable state, solve the effect of extremely low solubility

Pending Publication Date: 2022-07-08
SHANDONG FOOD & FERMENT IND RES & DESIGN INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Because astaxanthin exists in a crystalline state, the products obtained by the processing technology of these astaxanthin chewable tablets have extremely poor water solubility and poor bioavailability in the human body. Therefore, it is very necessary to find an effective method to improve the quality of astaxanthin bioavailability in humans

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The chewable tablet containing astaxanthin nanoparticles in this embodiment includes the following raw materials in weight fraction: astaxanthin: 0.4 part, octenyl succinic acid keratin ester: 0.2 part, sucrose fatty acid ester: 0.008 part , Hypromellose: 50 parts, Maltodextrin: 45.992 parts, White sugar: 2 parts, Microcrystalline cellulose: 1 part, Ethyl maltol: 0.1 parts, Magnesium stearate: 0.2 parts, Aspartame : 0.1 serving.

[0034] Step 1, add 30 parts of pure water in the batching tank, start stirring, weigh 0.4 parts of astaxanthin and put it into the batching tank, continue to stir and open the high-speed colloid mill to superfinely pulverize the astaxanthin in the water, and control the period. The feed temperature was 25°C.

[0035] In step II, the pulverized material in step I was filtered through a 200-mesh filter screen, and the filtrate was homogenized at 130 MPa through a homogenizer. After at least 8 times of homogenization, the homogenization was stop...

Embodiment 2

[0039] The chewable tablet containing astaxanthin nanoparticles in this embodiment includes the following raw materials in weight fraction: astaxanthin: 0.4 part, octenyl succinic acid keratin ester: 0.3 part, sucrose fatty acid ester: 0.012 part , Hypromellose: 50 parts, Maltodextrin: 45.888 parts, White sugar: 2 parts, Microcrystalline cellulose: 1 part, Ethyl maltol: 0.1 part, Magnesium stearate: 0.2 part, Aspartame : 0.1 serving.

[0040] Step 1, add 20 parts of pure water in the batching tank, start stirring, weigh 0.4 part of astaxanthin and put it into the batching tank, continue to stir and open the high-speed colloid mill to superfinely pulverize the astaxanthin in the water, and control the period. The feed temperature was 25°C.

[0041] In step II, the pulverized material in step I is filtered through a 200-mesh filter screen, and the filtrate is homogenized by a homogenizer at 130 MPa. After at least 8 times of homogenization, the homogenization is stopped. Alken...

Embodiment 3

[0045] The chewable tablet containing astaxanthin nanoparticles in this embodiment includes the following raw materials in weight fraction: astaxanthin: 0.4 part, octenyl succinic acid keratin ester: 0.4 part, sucrose fatty acid ester: 0.016 part , Hypromellose: 50 parts, Maltodextrin: 45.784 parts, White sugar: 2 parts, Microcrystalline cellulose: 1 part, Ethyl maltol: 0.1 part, Magnesium stearate: 0.2 part, Aspartame : 0.1 serving.

[0046] Step 1, add 10 parts of pure water in the batching tank, start stirring, weigh 0.4 part of astaxanthin and put it into the batching tank, continue to stir and open the high-speed colloid mill to superfinely pulverize the astaxanthin in the water, and control the period. The material temperature is 25℃;

[0047] In step II, the pulverized material in step I was filtered through a 200-mesh filter screen, and the filtrate was homogenized at least 8 times at 130 MPa by a homogenizer, and then the homogenization was stopped, and then 0.016 pa...

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Abstract

The invention relates to the field of biological pharmacy, in particular to a chewable tablet containing astaxanthin nanoparticles and a preparation method thereof.The preparation method comprises the steps that 0.4 part of astaxanthin is added into purified water to be smashed through a colloid mill, then 0.2-0.4 part of ester octenyl succinic acid curdlan and 0.008-0.016 part of sucrose fatty acid ester are added to be emulsified, then 45.784-45.992 parts of maltodextrin are added to be evenly mixed, then spray drying is conducted, and the chewable tablet containing the astaxanthin nanoparticles is obtained. And finally, uniformly mixing with 50 parts of hydroxypropyl cellulose, 1 part of microcrystalline cellulose, 0.1 part of ethyl maltol, 0.2 part of magnesium stearate and 2.1 parts of a sweetening agent, and tabletting to obtain the chewable tablets. No organic solvent is used in the whole production process, the processing cost is low, green and environment-friendly effects are achieved, and the bioavailability of astaxanthin can be improved.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to an astaxanthin-containing nanoparticle chewable tablet and a preparation method. Background technique [0002] Astaxanthin is a keto carotenoid, the chemical name is 3,3′-dihydroxy-4,4′-diketo-β,β′-carotene, red solid powder, fat-soluble, insoluble Water, soluble in organic solvents. Recent studies have shown that astaxanthin has many important physiological and biological functions such as anti-oxidation, anti-aging, anti-tumor and enhancing immunity. - 10 times the carotene, 17 times the grape seed, 75 times the lipoic acid, 200 times the lutein, 1000 times the vitamin E. Human aging is the degeneration and necrosis or apoptosis of cells caused by the imbalance of free radical generation and anti-oxidation in the body, the loss of cell function, and finally the aging of the entire body. Therefore, everyone's research on anti-aging starts from antioxidants, and the research ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/122A61K9/51A61K47/36A61P39/06A61P35/00A61P37/04
CPCA61K9/0056A61K9/2081A61K9/2059A61K9/5161A61K31/122A61P39/06A61P35/00A61P37/04
Inventor 兰文忠崔明浩孙曙光冀利王伟华苏理
Owner SHANDONG FOOD & FERMENT IND RES & DESIGN INST