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Display method of single-molecule chromatin microstructure

A chromatin and single-molecule technology, applied in the field of bioinformatics, can solve problems such as the complex spatial structure of chromatin and the inability to conduct in-depth and intuitive exploration and analysis of multiple chromatin complexes

Pending Publication Date: 2022-07-22
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the complexity of the spatial structure of chromatin, it is impossible to conduct in-depth and intuitive exploration and analysis of multiple chromatin complexes after existing analysis methods

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  • Display method of single-molecule chromatin microstructure
  • Display method of single-molecule chromatin microstructure
  • Display method of single-molecule chromatin microstructure

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Embodiment Construction

[0096] In the following description, for the purpose of illustration rather than limitation, specific details such as a specific system structure and technology are set forth in order to provide a thorough understanding of the embodiments of the present application. However, it will be apparent to those skilled in the art that the present application may be practiced in other embodiments without these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary detail.

[0097] It is to be understood that, when used in this specification and the appended claims, the term "comprising" indicates the presence of the described feature, integer, step, operation, element and / or component, but does not exclude one or more other The presence or addition of features, integers, steps, operations, elements, components and / or sets thereof.

[0...

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Abstract

The invention is applicable to the field of bioinformatics, and provides a single-molecule chromatin microstructure display method, which comprises the following steps: obtaining target chromosome region information, and obtaining target single-molecule chromatin complex information; obtaining target single-molecule chromatin information corresponding to the target chromosome region information from the target single-molecule chromatin complex information; performing clustering analysis processing on the target single-molecule chromatin information to obtain clustering matrix information; and according to the clustering matrix information, obtaining a display image corresponding to the chromatin microstructure of the target chromosome region information, and displaying the display image. According to the method, the data of the single-molecule chromatin complex is clustered so as to display the chromatin microstructure, the chromatin microstructure of the multi-chromatin complex can be visually browsed in real time, and the functions and characteristics of the multi-chromatin complex can be deeply and visually explored and analyzed.

Description

technical field [0001] The present application belongs to the field of bioinformatics, and in particular relates to a method for displaying single-molecule chromatin microstructure. Background technique [0002] The one-dimensional linear genome sequence of the entire human genome is linked together about 2 meters long and squeezed into a nucleus with a diameter of only about 10 micrometers. This 2-meter-long linear genome sequence is highly folded in the nucleus to regulate gene expression in an orderly manner, thereby ensuring the normal operation of cellular life. Three-dimensional genomics is an emerging discipline that studies how the genome folds and assembles in the nucleus to form a high-dimensional structure and then perform its functions. [0003] A new generation of 3D genome interaction technologies such as GAM, SPRITE and ChIA-Drop can detect interactions at multiple sites and accurately analyze the spatial structure of chromatin. However, due to the complexit...

Claims

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Application Information

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IPC IPC(8): G16B15/00G16B45/00G16B40/00
CPCG16B15/00G16B45/00G16B40/00
Inventor 田忠原郑梅珍
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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