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Compositions for reducing noxious sensation and/or other health benefits in infants and young children

A technology of composition, nutritional composition, applied in the direction of application, food science, function of food ingredients, etc.

Pending Publication Date: 2022-07-22
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, many of these medical interventions are painful for infants or young children and thus face recurrent and sometimes acute pain

Method used

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  • Compositions for reducing noxious sensation and/or other health benefits in infants and young children
  • Compositions for reducing noxious sensation and/or other health benefits in infants and young children
  • Compositions for reducing noxious sensation and/or other health benefits in infants and young children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0210] Example 1 HMO 2'FL increases the amount of KYNA (kynuric acid) produced by the microflora Fecal fermentation and kynurine Acid quantification

[0211] Fecal samples from 10 3- to 4-month-old infants (7 breast-fed (BF), 3 formula-fed (FF)) were used to inoculate YCFA medium without carbohydrates (without CHO) . The study design involved supplementing CHO-free YCFA medium with different carbohydrates at a final concentration of 0.5%, either lactose alone (F1 control) or a combination of 2'FL, 2'FL and LnNT, or Combinations of 2'FL, diFL, 3'SL, 6'SL, LNT and LNnT. Four replicate fermentations (F1 to F4) were performed on each individual and supernatants were collected after 24 and 48 hours. YCFA is a complex medium containing tryptone, yeast extract and various minerals, vitamins and short chain fatty acids; however, typical CHO components (glucose, maltose and cellobiose) are not included in this example.

[0212] For metabolite analysis, samples were extracted and...

Embodiment 2

[0216] 6′SL+LNT and KYNA have additive effects on GPR35 activation

[0217] method

[0218] Cell lines stably expressing GPR35 were expanded from frozen stocks according to standard procedures. Cells were seeded into white-walled 384-well microplates in a total volume of 20 μL and incubated at 37° C. for the appropriate time prior to testing. All tests are performed in duplicate. On each test day, 5x compound working intermediates were prepared in phosphate buffered saline (PBS) for each test concentration. 5 μL of 5x sample was added to cells and incubated for 90 minutes at 37°C or room temperature. Assay signals were generated by a single addition of 12.5 μL or 15 μL (50% v / v) PathHunter Detection Reagent Mix (DiscoverX) followed by one hour incubation at room temperature. Microplates were read after signal generation with a PerkinElmer EnvisionTM instrument for chemiluminescent signal detection. Compound activity was analyzed using the CBIS Data Analysis Suite (Che...

Embodiment 3

[0223] Table 1 below gives an example of the composition of a nutritional composition (eg, infant formula) according to the present invention. The composition is given by way of illustration only.

[0224] Table 1 : Composition of the infant formula of Example 1

[0225]

[0226]

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PUM

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Abstract

The present invention relates to a composition comprising 2 '-fucosyllactose (2'-FL) for reducing the nociceptive sensation in an infant or young child by increasing kynuric acid produced by microflora in an infant or young child eating a nutritional composition in the form of growing milk. The compositions are particularly useful for reducing abdominal pain, such as pain associated with infant colic, irritable bowel syndrome (IBS) and / or recurrent abdominal pain (RAP), and thus also contribute to reducing crying and improving sleep quality and overall quality of life in infants and young children.

Description

technical field [0001] The present invention relates to a composition comprising 2'-FL for promoting health benefits by increasing the production of kynuric acid by the microflora of an infant or young child consuming the composition. [0002] In particular, the present invention relates to compositions comprising 2'-FL that reduce the perception of nociception in infants or young children by increasing the production of kynuric acid by the microflora of the infant or young child consuming the compositions. [0003] The compositions are particularly useful for reducing abdominal pain, such as pain associated with bowel discomfort and / or bowel disturbance, and thus also help reduce crying periods and improve sleep quality and overall quality of life in infants and young children. [0004] The present invention also relates to a composition comprising 2'-FL for obtaining additional health benefits, such as for prevention and / or by increasing the production of kynuric acid by the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A23L33/00A61K31/702
CPCA23L33/40A23L33/10A23V2002/00A23V2250/28A23V2200/3202A61K31/702A61K2300/00A23L33/19A23L33/28
Inventor S·达马克N·斯普伦格F·福阿塔F·罗沙C·L·L·M·布朗格
Owner SOC DES PROD NESTLE SA