Temperature control device, liquid cooling temperature control system and PCR instrument
A technology of a temperature control device and a temperature control system, applied in the field of PCR instruments, can solve the problems of uneven heating, affecting the realization of gene amplification, etc.
Active Publication Date: 2022-08-05
鲲鹏基因(北京)科技有限责任公司
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Problems solved by technology
In the cooling liquid channel, the temperature of the cooling liquid near the cooling liquid inlet will be lower, and the temperature of the cooling liquid near the cooling liquid outlet will be higher due to heat absorption, which will cause uneven heating of each cuvette during the cooling process , thus affecting the realization of gene amplification
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[0034] Preferred embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While preferred embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
[0035] As used herein, the term "including" and variations thereof mean open-ended inclusion, ie, "including but not limited to". The term "or" means "and / or" unless specifically stated otherwise. The term "based on" means "based at least in part on". The terms "one example embodiment" and "one embodiment" mean "at least one example embodiment." The term "another embodiment" means "at least one additional embodiment." The terms "first", "se...
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The embodiment of the invention provides a temperature control device, a liquid cooling temperature control system and a PCR instrument. The temperature control device comprises a bottom plate provided with a cooling liquid inlet; the liquid storage cavity is arranged on the bottom plate, and a plurality of first through holes are formed in the top wall of the liquid storage cavity; the heat insulation layer comprises a plurality of second through holes corresponding to the first through holes; the confluence block is provided with a first side, a second side and a side surface and comprises a plurality of third through holes corresponding to the second through holes, a plurality of liquid return holes arranged in pairs with the third through holes, a confluence channel arranged in the confluence block and a cooling liquid outlet formed in the side surface; each liquid return hole extends into the confluence block from the second side and is communicated with the confluence channel, and the confluence channel is communicated with the cooling liquid outlet; the temperature control plate is arranged on the confluence block and used for providing a heat source; the heat conduction plate is arranged on the temperature control plate, a plurality of spiral flow channels are formed in the temperature control plate or the heat conduction plate, an inlet of each spiral flow channel corresponds to the third through hole, and an outlet of each spiral flow channel corresponds to the liquid return hole.
Description
technical field [0001] Embodiments of the present disclosure generally relate to the technical field of PCR instruments, and more particularly, to a temperature control device for a PCR instrument, a liquid-cooled temperature control system including the temperature control device, and a PCR instrument including the liquid-cooled temperature control system . Background technique [0002] The polymerase chain reaction (PCR) is a molecular biology technique used to amplify specific DNA fragments. It can be regarded as a special DNA replication in vitro. The biggest feature of PCR is that it can greatly increase the trace amount of DNA. . A PCR machine (also called a gene amplification machine) is used to implement such a reaction. [0003] In a PCR machine, it is usually necessary to perform gene amplification on multiple reaction consumables in parallel. In order to realize parallel gene amplification, a temperature control module needs to be used to control the temperatur...
Claims
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IPC IPC(8): C12M1/38C12M1/34C12M1/24C12M1/00
CPCB01L7/52B01L2300/18B01L2300/1844B01L2300/185B01L2300/1894
Inventor 朱信郭旻郭求真王梓戴涛陈衍娟
Owner 鲲鹏基因(北京)科技有限责任公司