Polyasparagine derivative containing high-activity hydrosy radical

Abstract

A polyasparagine derivative containing high-activity hydroxy radicals for medical purpose is disclosed, which features high power of carrying chemical medicine.

Description

1. Technical field: [0001] The invention relates to a medical polyamino acid polymer compound, in particular to a polyasparagine derivative rich in active hydroxyl groups. 2. Background technology: [0002] Polyamino acids and their derivatives are a new type of medical polymer compounds with excellent biocompatibility, can be completely degraded and absorbed when acting on organisms, and are non-toxic and have no side effects. [0003] At present, American Signam company has already listed poly(α,β-N-hydroxyethyl-DL-aspartamide) [Poly-(hydroxyethyl-DL-aspartamide, code name: PHEA), its main application is prodrug carrier and Plasma substitute, the structural formula is: [0004] [0005] Due to the structure of the side chain -NH-CH 2 -CH 2 OH is used as a carrier, so the number of hydroxyl groups is relatively small, which is not conducive to chemically bonding drugs, and the cost of preparation is high, and the sales price of finished products is expensive, above 10...

AI Technical Summary

Problems solved by technology

As the chain length of the non-polar substituent increases, the lipophilicity of these polyasparagine derivatives gradually increases, but their hydrophilicity decreases, which is not conducive to the chemical bonding of polar drugs.

[0007] To sum up, at present, various polyasparagine derivatives generally have the problem that the number of active hydroxyl groups on the side chain is relatively small, which is not conducive to chemically bonding drugs.

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