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Bromhexine hydrochloride injection and its preparation method

The technology of bromhexine hydrochloride and injection is applied in the field of bromhexine hydrochloride injection and preparation thereof, and can solve the problems of endangering the life of patients, complicated procedures, pollution of environment and equipment, etc.

Inactive Publication Date: 2005-01-19
张嵩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the mixing of liquid before intravenous injection, some disadvantages have been brought about. Not only is the procedure cumbersome, but also it is easily polluted by the environment and equipment. In severe cases, it can endanger the patient's life

Method used

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  • Bromhexine hydrochloride injection and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0077] Example 1: Preparation of concentrated glucose solution

[0078] Take 5000g of glucose for injection, add 15000ml of water for injection, stir to dissolve, add 45g of activated carbon and boil for 30 minutes, filter through a sand filter rod to decarbonize, and obtain a concentrated solution.

example 2

[0079] Example 2: Preparation of concentrated solution of bromhexine hydrochloride

[0080] Take an appropriate amount of absolute ethanol, heat it in a water bath to near boiling, add 16 g of bromhexine hydrochloride, stir to dissolve, and obtain a concentrated solution of bromhexine hydrochloride.

example 3

[0081] Example 3: Preparation of Bromhexine Hydrochloride Glucose Injection

[0082] Take the concentrated solution of glucose in Example 1 and the concentrated solution of bromhexine hydrochloride in Example 2 and combine, add water for injection to 100000ml, add 20g of activated carbon, stir well, keep the temperature for 30 minutes, filter, and use 0.1mol / L HCl and 0.1mol / L Adjust the pH value to 3.5-5.0 with LNaOH, measure the content of intermediates, filter through a 0.45μm microporous membrane, fill in infusion bottles or infusion bags, and sterilize at 115°C for 30 minutes. After cooling, light inspection, the finished product After the test, bromhexine hydrochloride glucose injection was obtained.

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Abstract

The present invention discloses a bromhexine hydrochloride injection and its preparation method. It is prepared by using bromhexine hydrochloride and medicinal carrier, and can be directly used for intravenous injection.

Description

technical field [0001] The invention relates to an injection and a preparation method thereof, in particular to a bromhexine hydrochloride injection and a preparation method thereof. Background technique [0002] Bromhexine hydrochloride is the preferred expectorant commonly used at home and abroad. It can decompose and break the acidic mucopolysaccharide fibers in sputum, and inhibit the synthesis of acidic mucopolysaccharides by glandular goblet cells, thereby reducing the viscosity of sputum and making it easier to cough up. This product still has nausea expectorant effect. It is mainly used for chronic bronchitis, asthma, bronchiectasis, silicosis and other patients with white sticky sputum that is difficult to cough up; it is especially suitable for surgical operations and critically ill patients. At present, there are dosage forms such as water injection and tablet for clinical use. There are bromhexine hydrochloride raw materials and tablets on page 691-693 of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61P11/10
Inventor 张嵩
Owner 张嵩
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