Method for preparing bis-tocopherol azelate and application of bis-tocopherol azelate
By preparing bistocopherol azelaate, the problems of poor permeability and high irritation in water-based systems were solved, and high purity and low cytotoxic compounds were achieved, expanding their potential in skin care and industrial applications.
Patent Information
- Application Number
- CN202510709759.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-29
- Publication Date
- 2025-07-29
- Estimated Expiration
- 2045-05-29
AI Technical Summary
Azelaic acid has poor permeability and high irritation in water-based systems, which limits its skin care and industrial applications, has high production costs and complex synthesis steps.
Bitocopherol azelaate was prepared, and the bitocopherol azelaic acid ester was reacted by reaction of tocopherol and azelaic acid chloride in dichloromethane solution, triethylamine and 4-dimethylaminopyridine were added as catalysts, and subsequent treatment was followed to obtain high-purity bitocopherol azelaate ester.
It improves the permeability and antioxidant properties of azelaic acid, reduces cell irritability, enhances the inhibitory effect of cell adipogenesis, improves the solubility in dibutyl adipic acid, and has a purity of more than 97.13%.