Preparation method and application of cucurbit[7]uril functionalized carbon paper electrode

By modifying β-mercaptoethylamine and gold nanoparticle assembly GNP@CB[7] on a carbon paper electrode, a cucurbit[7]urea-functionalized carbon paper electrode is formed, which solves the problems of specificity and cost in creatinine detection and realizes rapid, accurate and low-cost creatinine detection.

CN122193337APending Publication Date: 2026-06-12WUHAN UNIV OF SCI & TECH

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV OF SCI & TECH
Filing Date
2024-12-10
Publication Date
2026-06-12

AI Technical Summary

Technical Problem

Existing creatinine testing methods suffer from poor specificity, high cost, and long processing time, which limits their rapid and accurate application in the diagnosis of renal function and the evaluation of related diseases.

Method used

A cucurbit[7]urea-functionalized carbon paper electrode was formed by modifying the surface of carbon paper with β-mercaptoethylamine and gold nanoparticle assemblies (GNP@CB[7]). The electrode was used to recognize creatinine molecules and was combined with electrochemical detection technology to achieve rapid detection.

🎯Benefits of technology

It achieves highly sensitive, rapid, and low-cost detection of creatinine, is simple to operate, and is suitable for widespread application.

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Abstract

The application discloses a preparation method and application of a cucurbit[7]uril functionalized carbon paper electrode. The electrode comprises the following steps: taking carbon paper as a substrate, introducing beta-mercaptoethylamine modified gold nanoparticles loaded cucurbit[7]uril on the surface of the substrate after carboxylation. The high-sensitivity detection of creatinine is realized by detecting the impedance change generated after the recognition of creatinine by cucurbit[7]uril. The electrode has the advantages of high sensitivity, fast detection time and simple operation, and provides a new method for creatinine determination, and is suitable for popularization and use.
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