A method for preparing copper sulfide particles that can be used for photoacoustic imaging

By using L-cysteine ​​as a modifier in an aqueous phase to prepare copper sulfide nanoparticles, the biocompatibility and stability issues in existing technologies have been resolved, enabling efficient photoacoustic imaging applications and demonstrating good biocompatibility and light absorption performance.

CN122212221APending Publication Date: 2026-06-16UNIV OF ELECTRONICS SCI & TECH OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF ELECTRONICS SCI & TECH OF CHINA
Filing Date
2026-03-23
Publication Date
2026-06-16

AI Technical Summary

⚠Technical Problem

In the current preparation process of copper sulfide nanoparticles, organic modifiers with poor biocompatibility or synthetic modifiers with unknown biosafety are used, resulting in low biocompatibility, high potential toxicity, poor aqueous dispersion stability, and poor photoacoustic imaging performance of the materials.

⚗Method used

L-cysteine ​​was used as a modifier to prepare copper sulfide nanoparticles by reaction in an aqueous phase, including stirring, heating reaction and dialysis purification, to prepare copper sulfide nanoparticles with L-cysteine ​​modified surface.

🎯Benefits of technology

It achieves good biocompatibility, low toxicity, strong binding ability, good water dispersibility and physiological stability, is suitable for photoacoustic imaging, has a simple synthesis process, and possesses good near-infrared light absorption and photoacoustic signal.

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Abstract

The application belongs to the technical field of medical photoacoustic imaging nanomaterials, and provides a preparation method of copper sulfide particles for photoacoustic imaging. The problems of poor biocompatibility and difficult purification of organic modifiers such as oleic acid and oleylamine, unknown biosafety of synthetic modifiers such as polyethylene glycol, polyvinylpyrrolidone and sodium citrate, particle agglomeration, poor water phase dispersion stability and poor photoacoustic imaging performance in the preparation process of existing copper sulfide nanoparticles are solved. Copper nitrate trihydrate and L-cysteine are dissolved in water and stirred, sodium sulfide solution is added, and after stirring, the temperature is raised to 90 DEG C for 15 minutes, the reaction solution is cooled by ice water, and then dialysis purification is carried out, to obtain L-cysteine modified copper sulfide nanoparticles. The molar ratio of L-cysteine to copper nitrate trihydrate is 0.5:1 to 1.5:1, and the molar ratio of sodium sulfide to copper nitrate trihydrate is 1:1.
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