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Application of Funaosu in preventing and treating cadiovascular and cerebrovascular diseases

A technology for diseases and cerebral infarction, which is applied in the field of application of kaempferol-3-O-rutinoside in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases, and can solve problems such as no drugs for cardiovascular and cerebrovascular diseases

Inactive Publication Date: 2005-12-14
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to reports, it has analgesic and antiallergic activity (The Analgesic Activity of Hedyosmum bonplandianum: Flavonoid Glycosides, Cardenas L C, et al. Planta Med, 1993, 59 (1): 26-27. Antianaphylactic Effects of the Principal Compounds from the White Petals of Impatiens balsamina L.Fukumoto H, et al.Phytotherapy Research, 1996, 10 (3): 202~206), however, there has never been a report for the preparation of drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases

Method used

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  • Application of Funaosu in preventing and treating cadiovascular and cerebrovascular diseases

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Embodiment Construction

[0034]The kaempferol-3-O-rutinoside can be prepared by conventional methods to prevent and treat cardiovascular and cerebrovascular diseases. Funain can be mixed with a carrier or embedded with a carrier to make a composition. The carrier can be in the form of capsules or other loading forms. The carrier can be solid, semi-solid or liquid, as a diluent, excipient form or medium. The prepared composition can be in various forms such as tablet, injection, suspension and solution.

[0035] Various media, excipients or diluents can be used in the composition, such as: lactose, sucrose, sorbitol, mannitol, starch, polyethylene glycol, gelatin and the like. Lubricants, wetting agents, flavoring agents, suspending agents, preservatives, etc. can also be added to the formulations. The medicine made from the compound of the present invention can use any preparation method commonly used in the art to achieve the purpose of maximizing the efficacy of the active ingredients after being ...

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Abstract

The invention relates to the application of kaempferol-3-O-rutinoside in the preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases. Research shows that kaempferol-3-O-rutinoside has the effect on focal cerebral ischemia-reperfusion in rats. The injury has a strong protective effect, and can obviously reduce the blood viscosity of rabbits, prolong the coagulation time, protect vascular endothelial cells, and is non-toxic and safe to use, so it can be used to prepare drugs for preventing and treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of kaempferol-3-O-rutinoside in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases. technical background [0002] Kaempferol-3-O-rutinoside (kaempferol-3-O-rutinoside), the structural formula is: [0003] [0004] Molecular formula is C 27 h 30 o 15 , is a yellow needle crystal (MeOH), with a molecular weight of 594, soluble in ethyl acetate, ethanol, and methanol. [0005] The compound can be obtained from Compositae, Carthamus tinctorius, Ginkgo biloba, Impatiens balsamina, and Acanthopanax sieboldianus. Extracted from other plants. It is reported that it has analgesic and antiallergic activity (The Analgesic Activity of Hedyosmum bonplandianum: Flavonoid Glycosides, Cardenas L C, et al. Planta Med, 1993, 59 (1): 26-27. Antianaphylactic Effects of the Principal Compounds from the White Petals of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P9/10
Inventor 郭美丽张戈张汉明
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY