Andrographolide lactone microcapsule and its preparation method

Abstract

The invention relates to andrographolide microcapsules, which contain 14-77wt% of andrographolide and 23-86wt% of acrylic resin No. IV or acrylic resin E100. The preparation method is as follows: first dissolve acrylic resin in acetone, then add andrographolide and anti-adhesive agent to make a uniformly dispersed suspension; add the above suspension to liquid paraffin, evaporate to remove acetone, wash and dry to obtain required microcapsules. Or first dissolve the acrylic resin in ethanol, then add andrographolide and anti-sticking agent; atomize and dry the obtained mixture with air flow, and make the ethanol volatilize to obtain the desired microcapsules. The present invention adopts the acrylic resin which is soluble in acidic solution but insoluble in neutral or alkaline solution as the material of the microcapsule, so the prepared microcapsule hardly dissolves the drug in the aqueous solution and covers the bitter taste of the drug. And the in vitro dissolution is good. The microcapsules prepared by the invention can further develop andrographolide granules, suspensions and other preparation varieties suitable for children and patients with dysphagia.

Description

technical field [0001] The invention relates to andrographolide microcapsules and a preparation method thereof. Background technique [0002] Andrographolide is a lactone compound extracted from Andrographis paniculata, which is one of the main active ingredients of Andrographis paniculata. It has different degrees of anti-inflammatory effect, can inhibit the increase of capillary permeability in the early stage of inflammation, improve the state of exudation and edema, and has good curative effect on acute bacillary dysentery and acute enteritis. Mumps, acute and chronic pharyngitis, bronchitis, bacterial or viral pneumonia, etc. also have varying degrees of curative effect. Due to the definite curative effect of andrographolide, small adverse reactions, and no drug resistance, it is known as a natural antibiotic. Its clinical application is becoming more and more extensive, and it is welcomed by doctors and patients. [0003] The main adverse reaction of andrographolide ...

AI Technical Summary

Problems solved by technology

[0003] The main adverse reaction of andrographolide in clinical use is nausea due to extreme bitterness. Generally, methods such as coating the tablet or putting medicine into capsules are used to cover the bitter taste, but the andrographolide preparations prepared by these methods are not suitable for Medication for Children and Patients with Dysphagia

On the other hand, andrographolide is a water-insoluble compound, and the in vitro dissolution of general oral preparations is relatively poor, which affects its absorption by the gastrointestinal tract.

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