Unlock instant, AI-driven research and patent intelligence for your innovation.

Orally administered Modafinil medicine compostion

A technology of modafinil and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., which can solve problems such as difficulty in drinking water, difficulty in swallowing, and inability to take medicine.

Inactive Publication Date: 2006-08-02
GUILIN SANJIN PHARMACEUTICALS CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, modafinil is a long-term drug and may be used in special circumstances, such as night coach transport, night shifts, when a narcolepsy suffers from a premonition of an onset, when drinking water is unavailable or difficult, or The patient has difficulty swallowing
In the above and similar cases, it is inconvenient or even impossible to administer modafinil preparations with drinking water

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Modafinil Chewable Tablet No. 1

[0022]Modafinil 100g

[0023] Sucrose 200g

[0024] Mannitol 100g

[0025] Microcrystalline Cellulose 50g

[0026] Proper amount of hydroxypropyl methylcellulose (E30)

[0027] Appropriate amount of stevioside

[0028] Appropriate amount of menthol

[0029] Proper amount of vanillin

[0030] Talc powder 2g

[0031] Magnesium Stearate 1g

[0032] Prepared in 1000 pieces

[0033] Preparation process: pulverize modafinil, sucrose, mannitol and microcrystalline cellulose together, pass through a 100-mesh sieve, and mix well. A 1.5% hydroxypropyl methylcellulose solution in 80% ethanol was prepared, and stevioside, menthol, and vanillin were dissolved therein. Add this solution to the above mixed powder to prepare soft material, pass through 18 mesh sieve to prepare wet granules, dry in the air, granu...

Embodiment 2

[0035] Embodiment 2 Modafinil Chewable Tablet No. 2

[0036] Modafinil 200g

[0037] Lactose 100g

[0038] Mannitol 170g

[0039] Magnesium oxide 30g

[0040] Proper amount of polyvinylpyrrolidone (K30)

[0041] Sodium saccharin amount

[0042] Appropriate amount of menthol

[0043] Lemon essence amount

[0044] Talc powder 2g

[0045] Magnesium Stearate 1g

[0046] Prepared in 1000 pieces

[0047] The preparation process is similar to Example 1, specifically as follows. Grind modafinil, lactose, mannitol, and magnesium oxide together, pass through a 100-mesh sieve, and mix well. A 50% ethanol solution of 5% polyvinylpyrrolidone was prepared, and sodium saccharin, menthol, and lemon essence were dissolved therein. Add this solution to the above mixed powder to prepare soft materials, pass through a 18-mesh sieve to prepare wet granules,...

Embodiment 3

[0049] Example 3 Modafinil Orally Disintegrating Tablet No. 1

[0050] Modafinil 50g

[0051] Mannitol 50g

[0052] Microcrystalline Cellulose 200g

[0053] Low-substituted hydroxypropyl cellulose 20g

[0054] Sodium saccharin amount

[0055] Talc powder 2g

[0056] Magnesium Stearate 1g

[0057] Prepared in 1000 pieces

[0058] Preparation process: crush modafinil and mannitol together, pass through a 100-mesh sieve, and mix well. Then add microcrystalline cellulose and low-substituted hydroxypropyl cellulose and mix well. Sodium saccharin powder, talcum powder and magnesium stearate are mixed uniformly by equal volume addition method. The tablet is directly compressed with a 10mm shallow concave punch, and the tablet hardness is about 3kg.

[0059] The tablet was checked according to the disintegration time limit inspection method of "Chinese Pharmacopoeia 2000 Edition", ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
hardnessaaaaaaaaaa
hardnessaaaaaaaaaa
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention discloses an orally administered Modafinil medicine compostion wherein no drinking water is needed during use for oral application. The composition can be orally disintegrated, dispersed or dissolved. The does type of the medicinal preparation include chewing tablet, buccal tablet, oral rapid collapsing tablet or oral instant tablet and oral glue.

Description

technical field [0001] The invention relates to a medicinal composition containing modafinil that can be used in the oral cavity without drinking water during use. Background technique [0002] Modafinil (Modafinil), chemical name 2-[(diphenylmethyl)sulfinyl]acetamide, is a new type of central stimulant drug, mainly used for the treatment of narcolepsy, which can prolong the awakening state of patients. The oral tablet of this drug has been listed in many countries, and the trade name in the United States is Provigil, which is an oral tablet containing 100mg or 200mg. In addition to being used for the treatment of narcolepsy, modafinil also has a neuroprotective effect (US5180745), and it is also used as an antidepressant (Mitchell PB.NovelFrench antidepressants not available in the United States.PsychopharmacologyBulletin, 1995; 31( 3): 509-19). It has no dependence and sleep rebound phenomenon, which is completely different from the central stimulant drug amphetamine com...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/165A61K9/20A61P25/24A61P25/00
Inventor 金义光王林李淼彭涛
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD