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Kuhseng-targeting preparation and its preparing method

A technology of Sophora flavescens and preparations, which is applied in the field of Sophora flavescens targeted preparations and its preparation, which can solve the problems of drug delivery, lack of targeting, and lack of liver targeting of drugs, so as to change the peak and valley phenomenon, poor therapeutic effect, The effect of increasing drug safety

Inactive Publication Date: 2006-11-22
程怡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main reason why this stubborn fortress has not been conquered is that, in addition to the pharmacological effects of the therapeutic drug itself, the therapeutic drug is not effectively delivered to the lesion site and cells of the liver, that is, the drug lacks liver targeting or even no targeting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: Sophora flavescens targeting poly(n-butyl cyanoacrylate) nanosphere injection (by making 1000ml)

[0036] prescription:

[0037] Matrine: 200g

[0038] n-Butyl cyanoacrylate: 100ml

[0039] Sodium metabisulfite: 25g

[0040] Dextran-70: 100g

[0041] Preparation:

[0042]Mix 200g of matrine, 25g of sodium pyrosulfite, and 100g of dextran-70 in a beaker, add water for injection to dissolve, adjust the pH value to 2 with 0.1mol / L dilute hydrochloric acid, transfer it into the beaker, and slowly add cyano group under magnetic stirring n-butyl acrylate, after stirring at room temperature for 3 hours, adjust the pH value to 7 with 0.1mol / L dilute sodium hydroxide, and use G 3 Suction filtration through a vertical fused glass funnel, and add water for injection to 1000ml. Sophora flavescens targeting polycyanoacrylate n-butyl nanosphere injection.

Embodiment 2

[0043] Example 2: Sophora flavescens targeting polylactic acid nanospheres

[0044] prescription:

[0045] Oxymatrine: 100g

[0046] Polylactic acid: 50ml

[0047] Dichloromethane: 500ml

[0048] Polyvinyl alcohol: 50ml

[0049] Preparation:

[0050] First, polylactic acid was dissolved in volatile organic solvent dichloromethane to prepare a 10% solution, and 100 mg of oxymatrine was suspended in the solution. Then the obtained mixture is suspended in the stirring 1% polyvinyl alcohol solution, stirring constantly, the solvent is volatilized from the formed micro-droplets, centrifuged to obtain solid drug-loaded microspheres, collected microspheres and used Wash with deionized water, filter, and dry under vacuum at room temperature.

Embodiment 3

[0051] Embodiment 3: oxidized Sophora flavescens targeted liposome injection (by making 1000ml)

[0052] prescription:

[0053] Oxymatrine: 200g

[0054] Soy lecithin: 50g

[0055] Cholesterol: 125g

[0056] Methanol and chloroform: 50ml

[0057] Preparation:

[0058] Dissolve the prescribed amount of soybean lecithin, cholesterol, matrine, etc. in a mixed solvent of 50ml methanol and chloroform, pour it into a rotary thin film evaporator, and remove organic solvents such as methanol and chloroform under vacuum and reduced pressure at a temperature of 35°C , so that it forms a uniform dry film on the bottle wall; add 50ml of phosphate buffer, shake to form large multilayered liposomes, put it in a high-speed tissue masher, 12000r / min×2min×4 times, After standing, pass through a 0.45 μm microporous membrane to obtain a milky white uniform Sophora flavescens targeted liposome injection.

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PUM

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Abstract

A target medicine is prepared from flavescent sophora root and superfine particles as carrier. Its advantages are high target performance and biologic utilization rate, and no toxic by-effect to normal cells.

Description

technical field [0001] The invention relates to traditional Chinese medicine technology, in particular to a Sophora flavescens targeted preparation and a preparation method thereof. Background technique [0002] Sophora flavescens is derived from the root of Sophora flavescens Ait, the whole plant of Sophora flavescens L., the root of S.subprostrata Chur.Et T.Chen, the root of S. chrysophylla Seem.) bark, wood and bark of S. tetraptera F. Mill, aerial part of Japanese bean root (Euchresta japoni-ca Benth.). It has a variety of pharmacological effects and is widely used in the treatment of digestion, cardiovascular, central nervous, respiratory, and parasitic diseases. In recent years, Sophora flavescens and its active ingredients Sophora flavescens alkaloids have attracted people's attention in treating hepatitis B virus, improving liver cell function, resisting liver fibrosis, regulating the immune system and anti-tumor. As an anti-HBV drug, ginse...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61K9/14A61K9/50A61K9/127A61K9/19A61K9/00A61K47/42A61P1/16A61P31/12A61P35/00
Inventor 程怡
Owner 程怡