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Ginkgo leaf extract composition

A technology of extract and ginkgo biloba, which is applied in the field of pharmaceutical compositions containing ginkgo biloba extract and buxus nine, and can solve the problems such as no

Active Publication Date: 2006-12-06
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there have been development reports and patent documents of other dosage forms of Huang Yang Ning, such as injections, dripping pills, sustained-release preparations, etc., but the development of compound preparations of Huang Yang Ning is still relatively small, such as "Compound Huowei Bu Yang Ning" with application number 03112999.4 "Star D Tablet" is a compound composed of cyclovir buxicine and breviscapine, and there is no compound preparation of ginkgo leaf extract and boxwood, but the active ingredients of flavonoids and lactones in ginkgo leaf extract and boxwood Alkaloid active ingredients can produce synergistic therapeutic effects of different active ingredients and different mechanisms of action, and can strengthen the protective effect on cardiovascular and cerebrovascular cells

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take by weighing 1 gram of Buyang Ning and 2 grams containing more than 24% of flavonoids, and the Ginkgo biloba extract more than 6% of lactones and mix uniformly, then add an appropriate amount of dispersant (such as cross-linked polyvinylpyrrolidone, polyvinylpyrrolidone, polyethylene glycol Glycol 4000, Polyethylene Glycol 6000, etc.) to obtain a solid dispersion, weigh other tablet excipients and the solid dispersion in the same amount and mix uniformly, add a glidant and a lubricant, mix well, and press Sheet, make the compound recipe ginkgo leaf of about 1000.

Embodiment 2

[0017] Take by weighing 1 gram of Buyang Ning and 80 grams containing more than 24% of flavonoids, and the Ginkgo biloba extract more than 6% of lactones mix uniformly, then add an appropriate amount of dispersant (such as cross-linked polyvinylpyrrolidone, polyvinylpyrrolidone, polyethylene glycol Glycol 4000, Polyethylene Glycol 6000, etc.) are ground to obtain a solid dispersion, and other tablet adjuvants and solid dispersions are mixed uniformly in equal amounts by weighing the prescription amount, adding an appropriate amount of adhesive to make a soft material, and granulating, Add additional disintegrating agent and lubricant, mix well, compress tablet, make the compound recipe ginkgo leaf of about 1000.

Embodiment 3

[0019] Take by weighing 2 grams of Buyang Ning and 80 grams containing more than 24% of flavonoids, and the Ginkgo biloba extract of more than 6% of lactones mix uniformly, then add an appropriate amount of dispersant (such as cross-linked polyvinylpyrrolidone, polyvinylpyrrolidone, polyethylene glycol Glycol 4000, polyethylene glycol 6000, etc.) to obtain a solid dispersion, weigh other tablet excipients and the solid dispersion in the same amount and mix them uniformly, dry granulate, granulate, and add an additional disintegrant And lubricant, mixing, tabletting, the compound recipe ginkgo leaf of making about 1000.

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Abstract

The invention provides a pharmaceutical composition for treating cardiac and cerebral vascular diseases, which mainly comprises ginkgo leaves extract and Huangyangning by the weight ratio of 1 : 1-80, which contains flavones over 24%, delta-lactones over 6%.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition containing ginkgo leaf extract and boxywood. Background technique [0002] The diet structure of modern people has changed, the fat and calories in food have increased; the living conditions are relatively superior, and physical activity has decreased. Some unique diseases in modern life also follow, and the incidence of central and cerebrovascular diseases is increasing year by year. Since the 1990s, coronary heart disease, angina pectoris, and arrhythmia have become common clinical diseases and frequently-occurring diseases. The World Health Organization predicts that by 2020, cardiovascular diseases will be prevalent in developing countries, mainly stroke and coronary heart disease. [0003] Among the medicines for treating cardiovascular and cerebrovascular diseases, traditional Chinese medi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61K31/56A61P9/00A61P9/10A61K9/20
Inventor 王兵于琳冯汉林张丽娟杨锐黄传贵陈红李瑞文
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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