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Solid tumor treating medicine composition

A tumor and solid technology, applied in the direction of drug combination, antineoplastic drugs, drug delivery, etc., can solve the problem of systemic toxicity and side effects that limit clinical application

Inactive Publication Date: 2007-04-25
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the combination with other anticancer drugs has a certain effect on some tumors, the systemic side effects caused by conventional administration limit its clinical application

Method used

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  • Solid tumor treating medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Put 90 mg of medicinal excipient polylactic acid (PLA) with a molecular weight of 10000 into a container, add 100 ml of organic solvent to dissolve and mix with dichloromethane, add 10 mg of melphalan, shake again, and vacuum dry to remove the organic solvent. The dried solid composition is immediately shaped, and after packaging, it is ray sterilized to obtain a pharmaceutical composition for curing solid tumors containing 10% by weight of melphalan, which is used as a slow-release implant.

Embodiment 2

[0054] Example 2: As described in Example 1, the difference is that the components are one of the following, all of which are percentages by weight:

[0055] (A) 5-15% melphalan and 85-95% copolymer of polyglycolic acid and glycolic acid;

[0056] (B) 15-35% melphalan and 65-85% copolymer of polyglycolic acid and glycolic acid;

[0057] (C) 5-15% melphalan and 85-95% polylactic acid;

[0058] (D) 15-35% melphalan and 65-85% polylactic acid;

[0059] (E) 5-15% melphalan and 85-95% polystyrene;

[0060] (F) 15-35% melphalan and 65-85% polystyrene.

Embodiment 3

[0062] Put the weighing 85mg of medicinal excipient polylactic acid (PLA) with a molecular weight of 15000) into the container, add 100ml of organic solvent to dissolve in dichloromethane, add 15mg of melphalan, shake again and vacuum dry to remove the organic solvent . The dried solid composition is immediately shaped, and then irradiated to sterilize it after packaging to obtain a pharmaceutical composition for curing solid tumors containing 15% by weight of melphalan, which is used as a sustained-release implant.

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Abstract

The present invention is solid tumor treating medicine composition and belongs to the field of medicine technology. The medicine composition contains melphalan in effective anticancer amount and medicinal supplementary material. The medicinal supplementary material is mainly biocompatible, degradable and absorbable polymer, and during the degradation and absorption of the polymer, melphalan is released slowly to local tumor part to lower the systemic toxic reaction and to maintain local medicine concentration. The present invention has enhanced treating effect. The solid tumor includes cerebral tumor, liver cancer, lung cancer, esophagus cancer, gastric cancer, etc.

Description

(1) Technical field [0001] The invention relates to a pharmaceutical composition for treating solid tumors, and belongs to the technical field of medicines. (2) Background technology [0002] Although the research on cancer has made great progress, its mortality rate is still in the forefront of various common causes of death. In my country, about 1.6 million people suffer from cancer each year, and nearly 1.3 million people die from cancer, accounting for one-fifth of the total deaths. The incidence of cancer has increased year by year and is showing a trend of younger age. According to data, in less than 20 years, the incidence of cancer in my country has increased by 69%, and the mortality rate has increased by 29.4%. According to the latest statistics of the World Health Organization, the global cancer incidence will increase by 50% by 2020, and the number of cases will increase to 15 million. Therefore, exploring an effective method or drug for the treatment of cancer has be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K9/08A61K9/10A61K9/00A61P35/00
Inventor 孔庆忠
Owner DASEN BIOLOGICAL PHARMA CO LTD