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Functionalized cubic liquid crystalline phase materials and methods for their preparation and use

A liquid crystal phase, cubic technology, applied in chemical instruments and methods, food preparation, liquid crystal materials, etc., can solve the problems of no applicable cubic phase, enhanced deposition of active components, and no easy-to-commercial method

Inactive Publication Date: 2007-07-04
CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Additionally, there is no readily commercially available method to provide the specific purpose or enhance deposition of the active component from the cubic phase.
Finally, there is no cubic phase suitable for "as required" applications

Method used

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  • Functionalized cubic liquid crystalline phase materials and methods for their preparation and use
  • Functionalized cubic liquid crystalline phase materials and methods for their preparation and use
  • Functionalized cubic liquid crystalline phase materials and methods for their preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-

[0100] Example 1 - Generation of Cubic Complexes

[0101] Positively charged cubic complex gels - cubic complex gels are made of 0.16%, 0.32%, 0.57%, 0.95%, 1.22% and 3.92% dioctyldecylamine hydrochloride (DOAC*HCl) at 70:30 % w / w Monoolein: Made in water. All samples were determined to have cubic complex structure by SAXS and no birefringence by PLM. Comparable gels were made with the content of di(canola ethyl)dimethylammonium chloride (DEEDAC) and ketoprofen at higher concentrations. Surprisingly, the content of DEEDAC can be greater than 20%.

[0102] Negatively charged cubic complex gel - Negatively charged cubic complex gel was made by mixing 4% potassium oleate (K0l) into 60%: 40% monoolein and water. The gel was measured using SAXS to determine the structure of the resulting cubic complex.

[0103] Negatively Charged Cubic Complex Dispersion - A cubic complex gel base was prepared by melting 1.21433 g of monoolein in a small ampoule in a 40°C water bath. 0.20725 g...

Embodiment 2

[0104] Example 2 - Enhanced Cubic Complex Absorption Using Amine-Based Anchors

[0105] Cubic phase liquid crystals are prepared from a mixture of water and monoolein. Several cationic surfactants (i.e., dioctadecyldimethylammonium chloride (DODMAC), dioctadecylammonium chloride (DOAC), and bis(canola)dimethylamine Chloride (DEEDAC)) was incorporated into bicontinuous cubic liquid crystals to create a positively charged surface. Surfactant effects on ionized ketoprofen fillers were assessed by measuring the difference in partitioning of the active ingredient with and without surfactant inclusion. Dioctadecyldimethyl ammonium chloride and dioctadecyl dihydrogen chloride were prepared as cubic complexes by dissolving surfactants into liquid monoolein. Dioctadecyl ammonium dihydrochloride also makes a cubic phase as above. Surfactant effects on ionized ketoprofen fillers were assessed by measuring the difference in partitioning of active components with and without surfactant ...

Embodiment 3

[0106] Example 3 - Stabilized Disperse Cubic Complexes Using Loaded Oleate-Based Repellants

[0107] A mixture of potassium oleate (.20730 g), water (.60817 g) and monoolein (1.21320 g) was used as stock solution to make a 2% aqueous dispersion. A sample containing the stock mixture (.06963 g) diluted to 2% with water was prepared and sonicated for 3 hours to form a cubic complex dispersion. The control mixture was a 2% dispersion of monoolein and water, which was sonicated for three hours with water to form a cubic dispersion.

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Abstract

Functionalized cubic gel precursors, functionalized cubic liquid crystalline gels, dispersions of functionalized cubic gel particles and functionalized cubic gel particles are disclosed. Methods for preparing and using the precursors, gels, dispersions, and particles are also disclosed. The precursors, gels, dispersions, and particles are used to deliver active ingredients to substrates.

Description

field of invention [0001] The present invention relates to functionalized cubic liquid crystal phases and methods for their preparation and use. More particularly, the present invention relates to functionalized cubic liquid crystalline phase materials tailored for specific applications. Background of the invention [0002] The main reason for the interest in bicontinuous cubic liquid crystals is because of their unique structure. They are composed of a mixture of lipids and water arranged in a bilayer. The bilayer is then twisted into a looped three-dimensional structure that minimizes the energy associated with bending the bilayer (ie, minimizes bending energy). See Hyde, S., Andersson, S., Larrson, K., Blum, Z., Landh, T., Lidin, S., Ninham, B.W., The Language of Shape, Elsevier Press, New York, 1997. These structures are "honeycombs" with bicontinuous domains of water and lipids, resembling organic zeolites or highly structured microemulsions. Thus, the structure can...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K19/00A23L1/00A23L27/00A23L29/10A61K8/02A61K8/04A61K9/127A61K47/10A61K47/14A61K47/18A61K47/32A61K47/36A61K47/38A61K47/42A61Q19/00C09K19/02C09K19/54
CPCA61K8/0295A61Q19/00A23L1/22016Y10S514/964C09K19/54A23L1/035Y10S514/937A23L1/0032A61K8/042A61K9/1274C09K2019/528C09K19/00A23P10/35A23L29/10A23L27/72
Inventor M·L·林奇P·T·斯派塞
Owner CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI