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Rhizoma gastrodiae extract drop pill and preparing method thereof

A technology of gastrodin and dripping pills, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem of long disintegration time of tablets and capsules, affecting the therapeutic effect of gastrodin, dissolution rate and dissolution rate. problems such as low rate, to achieve the effects of convenience in carrying and taking, small pill volume, and improved dissolution rate and dissolution rate

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Gastrodin is odorless, bitter in taste, and easily soluble in water, but its tablets and capsules take a long time to disintegrate, have low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, Bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of gastrodin

Method used

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  • Rhizoma gastrodiae extract drop pill and preparing method thereof

Examples

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Comparison scheme
Effect test

example 1

[0052] prescription:

[0053] Gastrodin 5g

[0054] Macrogol 6000 15g

[0055] Makes 1000 capsules

[0056] Preparation method: Take gastrodin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as coolant, make pellets by dropping, dry, and obtain.

example 2

[0058] prescription:

[0059] Gastrodin 5g

[0060] Macrogol 4000 15g

[0061] Makes 1000 capsules

[0062] Preparation method: Take gastrodin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to molten polyethylene glycol 4000 matrix, stir well, use simethicone as coolant, make pellets by drop method, and dry to obtain.

example 3

[0064] prescription:

[0065] Gastrodin 5g

[0066] Macrogol 6000 5g

[0067] Macrogol 4000 10g

[0068] Makes 1000 capsules

[0069] Preparation method: Take gastrodin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone oil as the coolant, and make it dropwise Pills, dried, ready to use.

[0070] 4. Example 4

[0071] prescription:

[0072] Gastrodin 5g

[0073] Glyceryl monostearate 15g

[0074] Makes 1000 capsules

[0075] Preparation method: Take gastrodin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain.

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to produce gastrodin dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration, and its compliance property is good.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to gastrodin dripping pills and a preparation method thereof. Background technique [0002] Gastrodin can restore the imbalance between the excitatory and inhibitory processes of the cerebral cortex, and produce central inhibitory effects such as sedation, sleep and analgesia. [0003] Gastrodin is absorbed rapidly, and after 2 hours, only 5.2% of the administered dose remains in the gastrointestinal tract, and the blood concentration rises rapidly, t 1 / 2 α is 6 minutes, maintains a high level around 1 hour, and the elimination half-life is 7.47 hours. The distribution in the body is highest in the kidney, followed by the liver, lung, heart, spleen and brain. It is mainly excreted in urine, and the total excretion from urine, feces and bile is 76.8% of the administered dose, of which 97% is excreted in urine, mainly in the first 2 hours, and the bile and f...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7034A61P25/20
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG