High effect production method of catharanthine
A production method, the technology of vinblastine, applied in the direction of organic chemistry, etc., can solve the problems of complicated process, high production cost, low extraction rate and yield, and achieve the effect of simple method process, less solvent consumption and short production cycle
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Embodiment 1
[0031] Get new periwinkle 50kg (moisture content 70%) and 150kg of 70% ethanol extractant while mixing and put into a homogenizer to carry out homogenate extraction, and the homogenate is injected into a filter membrane with a cut-off component of 0.02~10 μm through a thick slurry pump. In an extraction tank with a negative pressure of 0.1MPa, negative pressure cavitation suspension extraction for 20-50 minutes, suction filtration, the material was subjected to cavitation suspension extraction with 70% ethanol 250kg, repeated this operation 2-3 times, combined the filtrate, vinblastine The extraction rate is 0.09-0.14‰, the filtrate is subjected to a temperature of 80-110°C, and a negative pressure of 0.06-0.1MPa. The solvent recovery tower concentrates and recovers ethanol. After adjusting the pH of the concentrated solution to 2 with sulfuric acid, the negative pressure cavitation suspension is carried out for 5-10 minutes. Stand still for 5 minutes, filter with suction, cont...
Embodiment 2
[0033] Get periwinkle 50kg (moisture content 40%) and sulfuric acid to be modulated into the 60% ethanol extractant 150kg of pH=2 and drop into homogenizer while mixing and carry out homogenate extraction, and homogenate is squeezed into with intercepted component through thick slurry pump. In an extraction tank with a filter membrane of 0.02-10 μm and a negative pressure of 0.1 MPa, negative-pressure cavitation suspension extraction for 20-50 minutes, suction filtration, and the material is subjected to cavitation suspension extraction of 250 kg of 60% ethanol with pH = 2, and the operation is repeated. After 2 to 4 times, the filtrates were combined. At this time, the extraction rate of vinblastine was 0.08 to 0.12‰. The temperature of the filtrate was 80 to 110°C, and the negative pressure was 0.06 to 0.1 MPa. After adjusting the pH value to 8-12 with ammonia water, let it stand for 5 minutes, filter with suction, separate the filtrate and filter cake, and put the filtrate a...
Embodiment 3
[0035]Take 15 kg of dried periwinkle and soak it with 30 kg of 50% ethanol extractant for 24 hours, then mix it with 50 kg of 50% ethanol extractant and put it into a homogenizer for homogenate extraction. In an extraction tank with a filter membrane of 10 μm and a negative pressure of 0.1 MPa, negative pressure cavitation suspension extraction for 20-50 minutes, suction filtration, and the material was subjected to cavitation suspension extraction with 150 kg of 50% ethanol. Repeat this operation 3 to 4 times, and combine Filtrate, the extraction rate of vinblastine is 0.08-0.12‰, the temperature of filtrate is 80-110°C, and the negative pressure is 0.06-0.1MPa Solvent recovery tower concentrates and recovers ethanol, sulfuric acid adjusts the concentrated solution to pH = 2, negative pressure cavitation suspension 5-10min, stand still for 5min, suction filter, continue to suspend with pH=2 aqueous solution and filter residue negative pressure cavitation for 2-3 times, combine...
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