Check patentability & draft patents in minutes with Patsnap Eureka AI!

Novel microsphere and method for production thereof

A technology of microspheres and derivatives, applied in the preparation of microspheres, pharmaceutical formulations, microcapsule preparations, etc., can solve problems such as improving the dispersion performance of microspheres

Inactive Publication Date: 2005-05-25
TAKEDA PHARMA CO LTD
View PDF28 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, these documents do not mention any method of improving the dispersion performance of microspheres

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel microsphere and method for production thereof
  • Novel microsphere and method for production thereof
  • Novel microsphere and method for production thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0284] In the following reference examples and examples, the weight-average molecular weight is determined by gel permeation chromatography (GPC) using monodisperse polystyrene as a reference (according to the molecular weight of polystyrene), and the content of each polymer is obtained from each weight-average Molecular weight calculations. Each measurement was performed in a high-efficiency GPC system (HLC-8120GPC, manufactured by Tosoh Corporation) using SuperH4000x2 and SuperH2000 columns (both manufactured by Tosoh Corporation), and a tetrahydrofuran mobile phase at a flow rate of 0.6 ml / min. Detection is based on differential refractive index.

reference example 1

[0285] Reference Example 1: Synthesis of High Molecular Weight Lactic Acid Polymer

[0286]To 230ml of dehydrated xylene, add 4.1ml of 1.0mol / l diethylzinc hexane solution, 1.35g of tert-butyl lactate and 230g of DL-lactide, and carry out polymerization at 120 to 130°C for about two hours . After the reaction was completed, 120 ml of dichloromethane was poured into the reaction liquid, and 230 ml of trifluoroacetic acid was added for deprotection reaction. After the reaction was completed, 300 ml of dichloromethane was added to the reaction liquid, which was then poured into 2800 ml of isopropyl ether, thus precipitating the desired product. Reprecipitation was performed with dichloromethane / isopropyl ether to obtain a lactic acid polymer with a weight average molecular weight of about 40,000.

reference example 2

[0288] The polymer obtained in Reference Example 1 was dissolved in 600 ml of methylene chloride. After the resulting solution was washed with water until neutral, 70 g of a 90% aqueous lactic acid solution was added and allowed to react at 40°C. When the weight average molecular weight of the polymer dissolved in the reaction liquid became about 20,000, the reaction liquid was cooled to room temperature, and 600 ml of dichloromethane was poured to stop the reaction. The reaction liquid was then washed to neutrality with water. After washing with water, the reaction liquid was concentrated to dryness to obtain a lactic acid polymer. In the resulting lactic acid polymer, the amount of terminal carboxyl groups was about 80 mol per gram of polymer, and the content of polymers having a weight average molecular weight of 5000 or less was 7.29% by weight.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
boiling pointaaaaaaaaaa
diameteraaaaaaaaaa
dispersityaaaaaaaaaa
Login to View More

Abstract

A method for producing microspheres with improved dispersibility is provided, characterized in that an osmotic pressure regulator is added to the external aqueous phase of the emulsion when producing the microspheres by a drying method in water.

Description

technical field [0001] The present invention relates to microspheres with improved dispersibility, methods for their production, sustained-release compositions containing the microspheres, and the like. Background technique [0002] For example, Japanese Patent Application Laid-Open (JP-A) Nos. 57-118512, 57-150609 and 6-145046 discloses a method for producing sustained-release W / O type emulsions using biodegradable polymers. [0003] The slow-release biodegradable polymer can be used as the base material of the microspheres coated with physiologically active substances and the like. Known examples of such biodegradable polymers include polylactic acid and copolymers of lactic acid and glycolic acid (for example, JP-A11-269094). [0004] Such biodegradable polymers are used per se after being produced by any conventional synthetic method. However, it has been found that this as-synthesized unmodified product has a low content of terminal carboxyl groups and is therefore un...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/52A61P13/00A61P13/08A61P35/00B01J13/12
CPCA61K9/1647A61P13/00A61P13/08A61P35/00B01J13/12A61K9/20A61K9/48A61K38/04
Inventor 布藤智康山本一路荒井次一
Owner TAKEDA PHARMA CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com