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Application and formulation of dammarane type gen-seng low valence alcohol derivative

A dammarane-type, derivative technology, applied in the field of medicine

Inactive Publication Date: 2005-07-06
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The patent application No. 93108189.0 found that the low alcohol derivatives of ginsenosides in Panax notoginseng have anticancer effects, but do these derivatives have other effects? Clearly this is a question worthy of further study

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Pharmacokinetic study of the preparation of the present invention

[0043] Experimental drug: take the tablet of the present invention (with Panaxadiol Potassium Succinate as raw material) and powder injection of the present invention (with Panaxatriol Sodium Succinate as raw material) as an example to carry out experiments

[0044] Experimental animals: 4 healthy male dogs, weighing 18-21kg.

[0045] Experimental method: get 2 dogs, the tablet of the present invention is given by intragastric administration according to the dosage of 6 mg / kg, blood is taken from a side forelimb vein at different times, heparin anticoagulant plasma is prepared, and panaxadiol is determined by high performance liquid chromatography Content, the blood concentration data at different times were automatically fitted on the Great Wall 0520CH computer (with the MCPKP program compiled by Xia Wenjiang, Lanzhou Institute of Traditional Chinese Veterinary Medicine, Chinese Academy of Agricultural...

Embodiment 2

[0067] Acute Toxicity Test

[0068] Experimental animals: healthy mice 18-22g, half male and half male.

[0069] Experimental drugs: tablets of the present invention, water injections, infusions, and powder injections (provided by the laboratory of some companies in Guangdong Tianzhijiao Drug Development)

[0070] Normal saline (provided by the laboratory of some companies in Guangdong Tianzhijiao drug development)

[0071] Experimental method: with tablet of the present invention according to 10 times, 20 times, 50 times of normal dosage, i.e. intragastric administration of 300mg / kg, 600mg / kg, 1500mg / kg, administration 3 times every day, continuously for 7 days, observe small Rat death situation, record data, calculate the LD50 of tablet of the present invention, see table 3; Similarly, inject preparation of the present invention according to 10 times, 20 times, 50 times of normal dosage, i.e. tail vein administration 15mg / kg, 30mg / kg, 75mg / kg, administered once a day, con...

Embodiment 3

[0095] Long-Term Toxicology Studies

[0096] Experimental animals: 8-week-old SD rats, weighing 100-120 g.

[0097] Experimental drugs: tablets of the present invention, water injections, infusions, and powder injections (provided by the laboratory of some companies in Guangdong Tianzhijiao Drug Development)

[0098] Normal saline (provided by the laboratory of some companies in Guangdong Tianzhijiao drug development)

[0099] Instrument: automatic biochemical analyzer (Hitachi 7600, JAPAN)

[0100] Experimental method: Take rats, take oral tablets and administer them by intragastric administration according to the dosage of 21 mg / kg (calculated according to the safe dosage for human administration), and administer the normal saline group by intragastric administration with equal volume and different volumes, 3 times a day , continuously for 16 weeks, observe the rats, without a case of death, the rats are dissected, and the tablet of the present invention is calculated to a...

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Abstract

The invention provides the novel use and formulation of dammarane type gen-seng low valence alcohol derivative, i.e. the use in treating cardiovascular and cerebrovascular diseases, wherein the preparation comprises extracting and separating panaxadiol, panaxatriol from notoginseng, then synthesizing panaxadiol glucopyranoside, panaxadiol potassium succinate, panaxatriol glucopyranoside, panaxatriol sodium succinate, the semisynthetics are used as raw material to prepare tablet, liquid injection, fluid infusion, and powder injection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use and preparation of dammarane-type saponin ginseng low-alcohol derivatives, that is, the application in the preparation of drugs for treating cardiovascular and cerebrovascular diseases and the preparation for treating cardiovascular and cerebrovascular diseases. technical background [0002] The chemical composition of traditional Chinese medicine is the material basis for its medicinal effect, and its in-depth research is the key and core of the modernization of traditional Chinese medicine; the research of chemical medicine requires screening from tens of millions of compounds, which requires a huge investment, and with the deepening of research and development , It is becoming more and more difficult to find new biologically active compounds, which brings great risks to investors. Therefore, senior experts at home and abroad turn their attention to natural ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K9/20A61K31/704A61P9/00
Inventor 张平
Owner 张平